Transfusion Cost Savings with Tranexamic Acid in Primary Total Knee Arthroplasty from 2009 to 2012

Successful treatment of bleeding with tranexamic acid in a series of 12 patients with immune thrombocytopenia

“…The drug is universally available, safe and highly effective in correcting hyperfibrinolysis . Most importantly, TA is inexpensive and has been proven to be effective in limiting transfusion necessities and costs in the perioperative setting . It remains unknown why TA is not included in the list of therapeutic options in ITP.…”

Tranexamic acid in adult elective orthopaedic and complex spinal surgery: A review

“…Studies by Harris and Moskal, et al revealed up to 96% cost reduction secondary to TXA use in total joint arthroplasty due to the offset of the high cost of transfusions and their possible complications with the relatively low cost of a dose of TXA ($39.14 per dose) [51,52]. Published cost reduction per patient associated with transfusion costs alone ranges from $83.73-$380.88 [17,52,53]. Cost reduction associated with transfusion and increased length of stay ranges from $730.00-$1235.98 [50,54,55].…”

“…Gillette examined costs associated with potential reductions in length of stay found that TXA use in TKA saved $457 in charges directly related to hospital stay [50]. Studies by Harris and Moskal, et al revealed up to 96% cost reduction secondary to TXA use in total joint arthroplasty due to the offset of the high cost of transfusions and their possible complications with the relatively low cost of a dose of TXA ($39.14 per dose) [51,52]. Published cost reduction per patient associated with transfusion costs alone ranges from $83.73-$380.88 [17,52,53].…”

Comparison of clinical results for patients undergoing unilateral total knee replacement with or without tranexamic acid

“…Besides, the longer hospitalization of stay made the patients at risk of pneumonia and more medical cost. 14 If the medical cost per day is 2,000 TWD (~66 USD) from the national health insurance, and the cost of intravenous TEA administration per dose (5 mg) is 10 TWD (~0.3 USD), then assuming 200 patients annually with unilateral TKA, there would be a cost saving of 160,000 TWD (~5,300 USD) in each hospital per year (i.e. 200/5 (total number/NNT) × 2000 × 2).…”