Transfusion‐acquired hepatitis C: the Danish lookback experience

Christensen, Peer Brehm; Groenbaek, Karin; Krarup, Henrik; Gaub, Janne E.; Møller, Axel; Skinhøj, Peter; Ring‐Larsen, Helmer; Dickmeiss, Dickmeiss; Wantzin, Per

doi:10.1046/j.1537-2995.1999.39299154734.x

Cited by 36 publications

(35 citation statements)

References 25 publications

(37 reference statements)

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“…Including undiagnosed patients the total estimate of patients with chronic hepatitis C corresponded to 0.38% of the adult population. The higher prevalence among men, persons 40–49years of age and residents in the capital region was in agreement with previous population surveys and the geographic distribution of hepatitis C infected Danish blood donors [3,18,19]. The South region had the highest proportion of young men.…”

Section: Discussionsupporting

confidence: 91%

“…Therefore we compared our estimates with a cohort of hepatitis C patients infected by blood transfusion and identified in the Danish hepatitis C look-back study [18]. Among 124 patients with diagnosed hepatitis C transmitted by transfusion 17% were not present in our source registers (compared to 24% in our estimate) and among a total of 187 recipients possibly infected (including 63 not tested) the four source registers identified 55% in agreement with the 54% estimate from the drug treatment register) (S Just, personal communication).…”

Section: Resultsmentioning

confidence: 99%

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Hepatitis C prevalence in Denmark -an estimate based on multiple national registers

et al. 2012

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BackgroundA national survey for chronic hepatitis C has not been performed in Denmark and the prevalence is unknown. Our aim was to estimate the prevalence of chronic hepatitis C from public registers and the proportion of these patients who received specialized healthcare.MethodsPatients with a diagnosis of chronic hepatitis C were identified from four national registers: a laboratory register, the Hospital Discharge Register, a clinical database of chronic viral hepatitis and the Register of Communicable Diseases. The total population diagnosed with hepatitis C was estimated by capture-recapture analysis. The population with undiagnosed hepatitis C was derived from the national register of drug users by comparing diagnosed and tested persons.ResultsA total of 6,935 patients diagnosed with chronic hepatitis C were identified in the four registers and the estimated population diagnosed with the disease was 9,166 persons (95% C.I. interval 8,973 – 9,877), corresponding to 0.21% (95% CI 0.21%-0.23%) of the Danish population over 15years of age. The prevalence was highest among persons 40–49years old (0.39%) and males (0.28%). It was estimated that 40% of the diagnosed patients lived in the capital region, and 33.5% had attended specialised healthcare. It was estimated that 46% of hepatitis C patients had not been diagnosed and the total population with chronic hepatitis C in Denmark was 16,888 (95% C.I. 16,474-18,287), corresponding to 0.38% (95% CI 0.37-0.42) of the population over 15years of age.ConclusionsThe estimated prevalence of chronic hepatitis C in Denmark was 0.38%. Less than half of the patients with chronic hepatitis C in Denmark have been identified and among these patients, one in three has attended specialised care.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Hepatitis C prevalence in Denmark -an estimate based on multiple national registers

et al. 2012

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“…The prevalence of anti-hepatitis C virus (HCV) antibodies among 4 drug users has been reported to be between 62% and 97% (19)(20)(21)(22). Patients with hemophilia, patients undergoing hemodialysis, multi-transfused patients and patients originating from high endemic areas also have an increased prevalence of HCV infection (20,23). Seroprevalence surveys of the general population are the gold standard for determining the number of HCV-infected individuals within a country.…”

Section: Chronic Hepatitis Bmentioning

confidence: 99%

Viral hepatitis in Denmark

Johansen¹,

Weis

Christensen³

2014

vhd

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Viral Hepatitis Journal, pub lis hed by Ga le nos Pub lis hing. DenmarkDenmark is a Scandinavian country with 5.6 million inhabitants (Figure 1). In total, 4.996.980 persons of the population are of Danish descent. Immigrants and their descendants constitute 567.932 persons. The life expectancy for women is 81.6 years and for men, 77.3 years.The basic principle of the Danish welfare system is that all citizens, free of charge, have equal rights and access to social security and health care. The Danish welfare model is subsidized by the state, and as a result, Denmark has one of the highest taxation levels in the world. Epidemiology of Viral HepatitisHepatitis A In Denmark, anti-HAV IgM positive hepatitis A virus (HAV) infection is a mandatory notifiable disease. HAV infection is not regarded as endemic in Denmark and susceptibility in the Danish population is high. The incidence declined during the last decades from 5.5 per 100.000 in 1980 to 0.2 per 100.000 in 2011, attributable to improved sanitary and living conditions ( ABSTRACT ÖZETTo provide an overview of the epidemiology and public health strategies concerning viral hepatitis in Denmark. Studies and guidelines in viral hepatitis in Denmark and national surveillance data were reviewed. The incidence of acute hepatitis A has declined since 1980 and was 0.2/105 in 2011. The majority of cases are imported by children of foreign origin. The incidence of acute hepatitis B has also been declining; the prevalence of chronic hepatitis B is estimated to be 0.24% of the adult population and genotype D is the most prevalent. The majority of patients with chronic hepatitis B are immigrants from high incidence regions and co-infection with hepatitis D is rare. The prevalence of hepatitis C is 0.38% of the adult population and the majority has been infected through 4 drug use. Genotype 1 is the most prevalent genotype. Hepatitis E is a rare and imported condition but a high prevalence of anti-HEV among farmers indicates the infection is an asymptomatic zoonotic infection in Denmark. There are national treatment guidelines for hepatitis B and C and the treatment is provided free of charge to all Danish residents. Vaccination against hepatitis A is recommended to persons travelling to high incidence countries and persons with chronic hepatitis C. Vaccination against hepatitis B is recommended and free of charge to all newborns of HBsAg positive mothers and persons specifically assessed to be at an increased risk. Denmark is a low incidence country for viral hepatitis, but continuous attention is required within risk groups. (

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“…56,57 However, in the United States, the effort appears to have been less productive. Consequently, if a blood donor is found to be HCV antibody positive, it is possible that prior donations from that individual were infectious for HCV.…”

Section: Lookbackmentioning

confidence: 99%