Transforming growth factor β1 preserves endothelial function after multiple brief coronary artery occlusions and reperfusion

Kenny, Dermot; Coughlan, M.; Pagel, Paul S.; Kampine, John P.; Warltier, David C.

doi:10.1016/0002-8703(94)90370-0

Cited by 27 publications

(15 citation statements)

References 23 publications

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“…In addition, VEGF can cause vasodilatation, partly through stimulation of nitric oxide synthase in endothelial cells, and can also stimulate cell migration and inhibit apoptosis [24]. It is expressed in developing blood vessels [25] and its receptors are found exclusively on endothelial cells [26,27]. When tissue is subjected to hypoxia or endothelial damage, expression of the VEGF protein is up-regulated [28].…”

Section: Discussionmentioning

confidence: 99%

The Adverse Effect of Selective Cyclooxygenase-2 Inhibitor on Random Skin Flap Survival in Rats

et al. 2013

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BackgroundCyclooxygenase-2(COX-2) inhibitors provide desired analgesic effects after injury or surgery, but evidences suggested they also attenuate wound healing. The study is to investigate the effect of COX-2 inhibitor on random skin flap survival.MethodsThe McFarlane flap model was established in 40 rats and evaluated within two groups, each group gave the same volume of Parecoxib and saline injection for 7 days. The necrotic area of the flap was measured, the specimens of the flap were stained with haematoxylin-eosin(HE) for histologic analysis. Immunohistochemical staining was performed to analyse the level of VEGF and COX-2 .Results7 days after operation, the flap necrotic area ratio in study group (66.65±2.81)% was significantly enlarged than that of the control group(48.81±2.33)%(P <0.01). Histological analysis demonstrated angiogenesis with mean vessel density per mm2 being lower in study group (15.4±4.4) than in control group (27.2±4.1) (P <0.05). To evaluate the expression of COX-2 and VEGF protein in the intermediate area II in the two groups by immunohistochemistry test .The expression of COX-2 in study group was (1022.45±153.1), and in control group was (2638.05±132.2) (P <0.01). The expression of VEGF in the study and control groups were (2779.45±472.0) vs (4938.05±123.6)(P <0.01).In the COX-2 inhibitor group, the expressions of COX-2 and VEGF protein were remarkably down-regulated as compared with the control group.ConclusionSelective COX-2 inhibitor had adverse effect on random skin flap survival. Suppression of neovascularization induced by low level of VEGF was supposed to be the biological mechanism.

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Section: Discussionmentioning

confidence: 99%

The Adverse Effect of Selective Cyclooxygenase-2 Inhibitor on Random Skin Flap Survival in Rats

et al. 2013

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“…Homeostatic levels of transforming growth factor (TGF)-β1, a pleiotropic cytokine that plays an important role in preserving endothelial function, are important in maintaining cardiac function. Excess production of TGF-β1 can enhance atherogenesis by promoting excessive extracellular matrix accumulation and lead to cardiac fibrosis (Kenny et al, 1994;Lijnen et al, 2000). It was reported that purified cocoa flavan-3-ols and procyanidins modulated TGF-β1 secretion from resting peripheral blood mononuclear cells, and these effects might potentially benefit cardiovascular health (Mao et al, 2003).…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Cocoa Phytochemicals: Recent Advances in Molecular Mechanisms on Health

Kim

Shim

et al. 2014

Critical Reviews in Food Science and Nutrition

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Recent reports on cocoa are appealing in that a food commonly consumed for pure pleasure might also bring tangible benefits for human health. Cocoa consumption is correlated with reduced health risks of cardiovascular diseases, hypertension, atherosclerosis, and cancer, and the health-promoting effects of cocoa are mediated by cocoa-driven phytochemicals. Cocoa is rich in procyanidins, theobromine, (-)-epicatechin, catechins, and caffeine. Among the phytochemicals present in consumed cocoa, theobromine is most available in human plasma, followed by caffeine, (-)-epicatechin, catechin, and procyanidins. It has been reported that cocoa phytochemicals specifically modulate or interact with specific molecular targets linked to the pathogenesis of chronic human diseases, including cardiovascular diseases, cancer, neurodegenerative diseases, obesity, diabetes, and skin aging. This review summarizes comprehensive recent findings on the beneficial actions of cocoa-driven phytochemicals in molecular mechanisms of human health.

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“…These human cell lines display the same phenotype as the murine and canine cell lines. They also express mesenchymal markers of osteoblasts such as osteocalcin and collagen Type 1 and 5 [55]. The cell lines maintain their expression of osteogenic marker proteins even after transplantation into NOD/SCID mice, where they can be retrieved from various parenchymal tissues.…”

Section: Tissue Formationsmentioning

confidence: 99%