Transforming growth factor-β1 gene polymorphism in renal transplant recipients

Chow, K. Martin; Szeto, Chris; Poon, P.W.F.; Leung, CM; Lai, Fernand Mac‐Moune; Li, P.K.T.

doi:10.1016/s1561-5413(09)60151-4

Cited by 4 publications

(4 citation statements)

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“…In recent years, the study of polymorphisms of genes involved in host immune responses, including cytokines and other modulators of the inflammatory response, has been the subject of interest, as these genetic markers may be potentially responsible for susceptibility or severity of acute disease .…”

Section: Introductionmentioning

confidence: 99%

Tumour necrosis factor-α plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients

Dalboni

Quinto

Grabulosa

et al. 2013

Clinical and Experimental Immunology

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SummaryGenetic polymorphism studies of cytokines may provide an insight into the understanding of acute kidney injury (AKI) and death in intensive care unit (ICU) patients. The aim of this study was to investigate whether the genetic polymorphisms of -308 G < A tumour necrosis factor (TNF)-a, -174 G > C interleukin (IL)-6 and -1082 G > A IL-10 may predispose ICU patients to the development of AKI and/or death. In a prospective nested case-control study, 303 ICU patients and 244 healthy individuals were evaluated. The study group included ICU patients who developed AKI (n = 139) and 164 ICU patients without AKI. The GG genotype of TNF-a (low producer phenotype) was significantly lower in the with AKI than without AKI groups and healthy individuals (55 versus 62 versus 73%, respectively; P = 0·01). When genotypes were stratified into four categories of TNF-a/IL-10 combinations, it was observed that low TNF-a plus low IL-10 producer phenotypes were more prevalent in patients with AKI, renal replacement therapy and death (P < 0·05). In logistic regression analysis, low TNF-a producer plus low IL-10 producer phenotypes remained as independent risk factors for AKI and/or death [odds ratio (OR) = 2·37, 95% confidence interval (CI): 1·16-4·84; P = 0·02] and for renal replacement therapy (RRT) and/or death (OR = 3·82, 95% CI: 1·19-12·23; P = 0·02). In this study, the combination of low TNF-a plus low IL-10 producer phenotypes was an independent risk factor to AKI and/or death and RRT and/or death in critically ill patients. Our results should be validated in a larger prospective study with long-term follow-up to emphasize the combination of these genotypes as potential risk factors to AKI in critically ill patients.

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Section: Introductionmentioning

confidence: 99%

Tumour necrosis factor-α plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients

Dalboni

Quinto

Grabulosa

et al. 2013

Clinical and Experimental Immunology

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“…Accordingly, Park et al (24) found the frequency of TGFB1 lower and of intermediateproducing genotypes (codon 10 CC and codon 25 GG) to be significantly higher in patients with recurrent acute rejection episodes, whereas high producer genotypes were increased in donors of patients with chronic renal allograft dysfunction. It is interesting to point out that this same high producer TGFB1 codon 10 T allele, when present in homozygosis in renal transplant recipients, was reported to be a potential risk for allograft function decline (25) . These heterogeneous data may, at least in part, reflect the effect of other relevant factors in CAN, including the positive or negative effect of other gene polymorphisms.…”

Section: Resultsmentioning

confidence: 99%

Contrasting roles of donor and recipient TGFB1 and IFNG gene polymorphic variants in chronic kidney transplant rejection

Coelho

Ioschpe

Caldas

et al. 2011

Einstein (São Paulo)

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Objective: To assess the long-term impact (minimum of 3 years follow-up) of polymorphisms in cytokine genes in donor:recipient pairs on the results of the transplant. Methods: We compared genetic cytokine polymorphisms and the primary factors of risk for the development of chronic rejection in paired groups of renal transplant patients with and without chronic allograft nephropathy [CAN]. Results: Multivariate analysis indicated that the presence of the highproduction TT genotype (codon 10) of the transforming growth factor beta-1 (TGFB1) was protective in receptors (p=0.017), contrasting with the increased risk when present in donor samples (p=0.049). On the other hand, in the case of the gamma interferon studied, the greater frequency of the high production allele was protective in the analysis of the donor group (p=0.013), increasing the risk of chronic nephropathy of the allograft when present in the recipients (p=0.036). Conclusion: Our results highlight the importance of TGFB1 genotyping in donors, and indicate that polymorphisms in the gene of this cytokine in donor cells might contribute to the development of chronic allograft nephropathy

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“…There were 18 studies [20,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] about the relationship between TGF-β1 + 869 T/C gene polymorphism and risk of acute rejection in patients with renal transplant (Fig. 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients

Zhou

Lin

et al. 2019

BMC Med Genet

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Background: This meta-analysis was conducted to assess the relationship between the transforming growth factorbeta 1 (TGF-β1) + 869 T/C gene polymorphism, + 915 G/C gene polymorphism, and the susceptibility of acute rejection in the recipients with renal transplantation. Methods: Relevant studies were searched and identified from the Cochrane Library and PubMed, and eligible investigations were recruited and data were calculated by meta-analysis. Results: In this study, we found no relationship between either TGF-β1 + 869 T/C or TGF-β1 + 915 G/C gene polymorphism and acute rejection susceptibility in patients with renal transplantation. No association between either gene polymorphism and acute rejection susceptibility in patients with renal transplantation in Caucasian, Asian, or African populations individually was found. Conclusion: The TGF-β1 + 869 T/C and + 915 G/C gene polymorphisms are not associated with acute rejection susceptibility in recipients with renal transplantation.

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Transforming growth factor-β1 gene polymorphism in renal transplant recipients

Cited by 4 publications

References 0 publications

Tumour necrosis factor-α plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients

Tumour necrosis factor-α plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients

Contrasting roles of donor and recipient TGFB1 and IFNG gene polymorphic variants in chronic kidney transplant rejection

Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients

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