Transforming growth factor β receptor induction in herniated intervertebral disc tissue: an immunohistochemical study

Oncoprotein c-Fos and c-Jun immunopositive cells and cell clusters in herniated intervertebral disc tissue

“…In the present study, we show the expression of the oncoproteins c-Fos and c-Jun in herniated disc tissue. We have previously reported expression of TGF-β and induction of TGF-β receptor in these same tissues [23]. This may suggest that the proliferative effect of TGF-β is at least partly mediated by these oncoproteins in herniated disc tissue as well.…”

The effect of exogenous melatonin administration on trabecular width, ligament thickness and TGF-β1 expression in degenerated intervertebral disk tissue in the rat

“…18,23,[28][29][30] Recently, Nakade et al 31 demonstrated that this hormone has a putative role in collagen synthesis in human bone cells in vitro. Furthermore, it has been suggested that it plays an important part in the stimulation of synthesis of ECM and related molecules, including TGF-b 1 , tenascin and fibronectin and also in regulation of ECM construction.…”

Herniated and Spondylotic Intervertebral Discs of the Human Cervical Spine: Histological and Immunohistochemical Observations

“…Invasion of the avascular disc tissue by blood vessels suggests certain immunological reaction(s) in response to the development of hernias and the intervertebral disc degradation [11,27]. There is some evidence to suggest that endothelial cell growth is enhanced by several cytokines such as fibroblast growth factor (FGF) [27], transforming growth factor (TGF)-b [29], platelet-derived growth factor [28] and vascular endothelial growth factor (VEGF) [14,28]. Tolonen et al [28] demonstrated that VEGF participates in angiogenesis in the herniated intervertebral discs.…”