Transforming growth factor‐β in benign and malignant prostate

Lee, Chung; Sintich, Sharon M.; Mathews, Eric P.; Shah, Amit; Kundu, Shilajit; Perry, Kent T.; Cho, Jin Seon; Ilio, Kenneth Y.; Cronauer, Marcus V.; Janulis, Lynn; Sensibar, Julia A.

doi:10.1002/(sici)1097-0045(19990601)39:4<285::aid-pros9>3.3.co;2-z

Cited by 14 publications

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“…TGF-β 1 is the predominant isoform in the TGF-β family and plays an important role in the regulation of prostatic differentiation and prostate cancer cell growth [112][113][114]. In benign prostatic epithelium, its action is mediated through a paracrine mechanism, where it inhibits proliferation and induces apoptosis in the prostate epithelium [115].…”

Section: The Role Of Epithelial-stromal Interactions In the Differentmentioning

confidence: 99%

Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies

et al. 2004

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Prostate cancer is the most common malignancy in males in the western world. However, little is known about its origin and development. This review highlights the biology of the normal prostate gland and the differentiation of basal epithelial cells to a secretory phenotype. Alterations in this differentiation process leading to cancer and androgen-independent disease are discussed, as well as a full characterization of prostate epithelial cells. A full understanding of the origin and characteristics of prostate cancer epithelial cells will be important if we are to develop therapeutic strategies to combat the heterogeneous nature of this disease.

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Section: The Role Of Epithelial-stromal Interactions In the Differentmentioning

confidence: 99%

Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies

et al. 2004

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“…In addition, it has been shown that TGF-β blocked the proliferative effect of androgen on prostate smooth muscles (Gerdes et al, 1998) and induced their differentiation (Hisataki et al, 2004;Untergasser et al, 2005). Despite the association of TGF-β expression with prostate cancer cell death (Kyprianou et al, 1990), alteration of TGF-β expression has been implicated in reactive stroma, which is associated with prostate cancer (Tuxhorn et al, 2002;Wikstrom et al, 2001), and benign prostate hyperplasia (Lee et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Testosterone effect on immature prostate gland development associated with suppression of transforming growth factor-β

Shidaifat

AL-Trad

Al-Omari³

2007

Life Sciences

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“…Owing to the combination of different cell types, BPH stromal nodules can be designated as undifferentiated, fibrous, fibromuscular, and muscular. Our future studies will focus on the role of various growth factors, such as fibroblastic growth factors, keratinocyte growth factor, or transforming growth factor‐β, in the process of the development of stromal nodules (24–27).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Characterization of Stromal Nodules in Benign Prostatic Hyperplasia

Kong¹,

Zeng²,

Yang³

et al. 2000

Prostate J

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The goal of this study is to characterize stromal nodules in benign prostatic hyperplasia (BPH) in a Chinese population. BPH specimens were obtained by superpubic enucleation. Immunohistochemical staining for vimentin, muscle actin (HHF35), and smooth muscle actin (1A4) was conducted in serial sections of 55 consecutive stromal nodules of BPH specimens. The simplest stromal nodules were undifferentiated nodules that contained vimentin-negative and smooth muscle actin-negative cells. These cells were designated as undifferentiated mesenchymal cells. Immunohistochem-ical staining identified two cell types. Smooth muscle cells contained smooth muscle actin and vimentin, while fibrocytes contained vimentin but not smooth muscle actin. Fibrous nodules contained fibrocytes. Two more types of stromal nodules were fibromuscular nodules, which contained mixtures of fibrocytes and smooth muscle cells, and muscular nodules, which contained only smooth muscle cells. Of 55 stromal nodules, 11 (20%) were undifferentiated, 5 (9%) were fibrous, 37 (67%) were fibromuscular, and 2 (4%) were muscular.

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Transforming growth factor‐β in benign and malignant prostate

Cited by 14 publications

References 0 publications

Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies

Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies

Testosterone effect on immature prostate gland development associated with suppression of transforming growth factor-β

Immunohistochemical Characterization of Stromal Nodules in Benign Prostatic Hyperplasia

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