2006
DOI: 10.2337/diabetes.55.01.06.db05-0189
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Transforming Growth Factor-β and Natural Killer T-Cells Are Involved in the Protective Effect of a Bacterial Extract on Type 1 Diabetes

Abstract: The onset of type 1 diabetes in NOD mice is delayed by oral administration of a bacterial extract (OM-85) and can be completely prevented by its intraperitoneal administration. Optimal prevention is observed when starting treatment at 3 or 6 weeks of age, and some effect is still observed with treatment at 10 weeks of age. Using genetically deficient mice and cytokine-neutralizing monoclonal antibodies, we demonstrate here that the therapeutic effect does not involve T-helper type 2 cytokines (interleu- kin

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Cited by 82 publications
(66 citation statements)
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“…Complete Freund's adjuvant [84] Streptococcal OK-432 [85] Klebsiella pneumonia glycoprotein [86] Escherischia coli LPS [86] Zymosan [87] Zymosan [88] CpG DNA [89] CpG DNA [90] Polyinosinic:polycytidylic acid [80] OM-85 (multi-species extract) [91] Pseudomonas aeruginosa OdDHL [92] Legend: LNFPIII -lacto-N-fucopentaose III, BCG -baccilus calmette-guerin, LPS -lipopolysaccharide, OdDHL -N-(3-oxododecanoyl)-L-homoserine lactone.…”
Section: Bovis Bcg [82 83]mentioning
confidence: 99%
“…Complete Freund's adjuvant [84] Streptococcal OK-432 [85] Klebsiella pneumonia glycoprotein [86] Escherischia coli LPS [86] Zymosan [87] Zymosan [88] CpG DNA [89] CpG DNA [90] Polyinosinic:polycytidylic acid [80] OM-85 (multi-species extract) [91] Pseudomonas aeruginosa OdDHL [92] Legend: LNFPIII -lacto-N-fucopentaose III, BCG -baccilus calmette-guerin, LPS -lipopolysaccharide, OdDHL -N-(3-oxododecanoyl)-L-homoserine lactone.…”
Section: Bovis Bcg [82 83]mentioning
confidence: 99%
“…30 Furthermore, the optimal prevention of diabetes by oral administration of a bacterial extract was observed before six weeks of age in non-obese diabetic (NOD) mice. 31 These interventions are most prominent in the pre-diabetic stage, suggesting that early life events during microbial colonization and development of the immune system are relevant in modifying autoimmune diabetes risk. In addition to this, we have previously demonstrated that vancomycin treatment of NOD mice attenuated diabetes development when they are treated only before weaning, 32 and in a recent study neonatal vancomycin treatment was also shown to enhance susceptibility to murine allergic asthma.…”
Section: Future Applicationmentioning
confidence: 99%
“…Furthermore, Alyanakian et al found that bacterial extract (OM-85) administered orally delayed the onset of Type 1 diabetes, while intraperitoneal administration initiated at 3 or 6 weeks of age prevented it completely [3]. The mechanism involved both transforming growth factor (TGF)-β and natural killer T (NKT) cells [3].…”
Section: Evidence From Animal Studiesmentioning
confidence: 99%