Transforming growth factor‐β activated long non‐coding RNA ATB plays an important role in acute rejection of renal allografts and may impacts the postoperative pharmaceutical immunosuppression therapy

Qiu, Jian; Chen, Ye‐Hui; Huang, Gang; Zhi, Zhang; Chen, Lizhong; Na, Ning

doi:10.1111/nep.12851

Cited by 36 publications

(30 citation statements)

References 28 publications

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“…TCONS_00088786 and TCONS_01496394 are TGF-β/Smad3-associated lncRNAs as they contain potential binding sites for Smad3 and silencing TCONS_00088786 inhibits renal interstitial fibrosis by targeting miR-132 (Sun et al, 2017;Zhou S.G. et al, 2018). lncRNA-ATB is highly upregulated in patients with acute renal allograft rejection and renal carcinoma and is able to promote EMT (Qi et al, 2017;Qiu et al, 2017;Zhou and Jiang, 2019). lncRNA uc.412 is able to induce mesangial cell proliferation in vitro although the underlying mechanisms are unclear .…”

Section: Diverse Role Of Tgf-β/smad Signaling In Regulation Of Non-comentioning

confidence: 99%

Diverse Role of TGF-β in Kidney Disease

Liu

Huang

et al. 2020

Front. Cell Dev. Biol.

157

132

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Section: Diverse Role Of Tgf-β/smad Signaling In Regulation Of Non-comentioning

confidence: 99%

Diverse Role of TGF-β in Kidney Disease

Liu

Huang

et al. 2020

Front. Cell Dev. Biol.

157

132

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“…Qiu et al [132] propose that lncRNA-ATB, activated by TGF-β1, could be used as a novel diagnostic biomarker to identify the severity of inflammation and fibrosis. Some studies investigated lncRNA-ATB, a lncRNA associated with liver fibrosis and HCC, in HCV patients and identified that plasma levels of this lncRNA were significantly correlated with the stage of liver fibrosis [133,134].…”

Section: Lncrna-atbmentioning

confidence: 99%

LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

Kim

Park

Lee

2020

IJMS

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Long non-coding RNAs (lncRNAs) are emerging as important contributors to the biological processes underlying the pathophysiology of various human diseases, including hepatocellular carcinoma (HCC). However, the involvement of these molecules in chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD) and viral hepatitis, has only recently been considered in scientific research. While extensive studies on the pathogenesis of the development of HCC from hepatic fibrosis have been conducted, their regulatory molecular mechanisms are still only partially understood. The underlying mechanisms related to lncRNAs leading to HCC from chronic liver diseases and cirrhosis have not yet been entirely elucidated. Therefore, elucidating the functional roles of lncRNAs in chronic liver disease and HCC can contribute to a better understanding of the molecular mechanisms, and may help in developing novel diagnostic biomarkers and therapeutic targets for HCC, as well as in preventing the progression of chronic liver disease to HCC. Here, we comprehensively review and briefly summarize some lncRNAs that participate in both hepatic fibrosis and HCC.

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“…A growing body of evidence indicates that lncRNAs could regulate gene expression at the transcriptional and/or post-transcriptional levels, and play fundamental roles in a diverse array of biological processes such as cell cycle control, development, carcinogenesis, and immune response [12-15]. A large number of dysregulated lncRNAs have been identified in the renal cortex tissues of AR recipients [16-18]. Recently, Lorenzen and colleagues have analyzed the lncRNA expression profiles in the urine of renal transplant recipients, and demonstrated that urinary RP11-354P17.15-001 could serve as a novel biomarker of acute T cell-mediated rejection (ATMR) of renal allografts [19].…”

Section: Introductionmentioning

confidence: 99%

A Molecular Signature of Two Long Non-Coding RNAs in Peripheral Blood Predicts Acute Renal Allograft Rejection

Cao

et al. 2017

Cell Physiol Biochem

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Background/Aims: Acute rejection (AR) is a major complication post renal transplantation, with no widely-accepted non-invasive biomarker. This study aimed to explore the expression profiles of long non-coding RNAs (lncRNAs) in the peripheral blood (PB) of renal transplant recipients and their potential diagnostic values. Methods: The genome-wide lncRNA expression profiles were analyzed in 150 PB samples from pediatric and adult renal transplant (PRTx and ARTx) cohorts. The diagnostic performance of differentially expressed lncRNA was determined using receiver operator characteristic curve, with area under the curve (AUC) and 95% confidential interval (CI). Finally, a risk score was constructed with logistical regression model. Results: A total of 162 lncRNAs were found differentially expressed in PRTx cohort, while 163 in ARTx cohort. Among these identified lncRNAs, 23 deregulated accordingly in both cohorts, and could distinguish AR recipients from those without AR. Finally, a risk score with two most significant lncRNAs (AF264622 and AB209021) was generated and exhibited excellent diagnostic performance in both PRTx (AUC:0.829, 95% CI:0.735-0.922) and ARTx cohorts (AUC: 0.889, 95% CI: 0.817-0.960). Conclusion: A molecular signature of two lncRNAs in PB could serve as a novel non-invasive biomarker for the diagnosis of AR in both pediatric and adult renal transplant recipients.

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Transforming growth factor‐β activated long non‐coding RNA ATB plays an important role in acute rejection of renal allografts and may impacts the postoperative pharmaceutical immunosuppression therapy

Abstract: In conclusion, lncRNA-ATB are strongly altered in patients with acute rejection and may serve as a novel biomarker of acute kidney rejection, identifying patients with acute rejection and predicting loss of kidney function.

Cited by 36 publications

References 28 publications

Diverse Role of TGF-β in Kidney Disease

Diverse Role of TGF-β in Kidney Disease

LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

A Molecular Signature of Two Long Non-Coding RNAs in Peripheral Blood Predicts Acute Renal Allograft Rejection

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