Transforming growth factor-α and epidermal growth factor inhibit gastric acid secretion and stimulate release of somatostatin and neurotensin in the conscious rat

Bacterial colonization and healing of gastric ulcers: the effects of epidermal growth factor

“…In addition to its anti-infective properties and proliferative effects on tissues, EGF is capable of regulating gastric acid secretion. After short-term administration of EGF, inhibition of agonist-stimulated acid secretion has been observed in vivo in humans (24), dogs (26), and rats (12) and in vitro in parietal cells or gastric glands from guinea pigs (9), rats (40), and rabbits (5). In vitro findings suggest that EGF exerts a direct effect on the parietal cell to reduce acid secretion (48).…”

Human transforming growth factor alpha (TGF-alpha) is digested to a smaller (1-43), less biologically active, form in acidic gastric juice

“…The lower dose of TGF-α probably did not affect gastric acid secretion 31 but the higher dose may have done so because 1.8 µmol/kg/h of TGF-α 1-50 , administered intravenously, decreases gastric acid secretion by 72%. 31 This may be relevant to the mechanism by which TGF-α decreased gastric damage in our rat model as we have previously shown the damage to be acid dependant. 15 Cleavage of the terminal seven amino acids of TGF-α caused a 3-5 fold reduction in its ability to reduce injury in this model, which was similar to the reduction in activity found using the in vitro assay.…”

Expression of gallus epidermal growth factor (gEGF) with food-grade Lactococcus lactis expression system and its biological effects on broiler chickens

“…Furthermore, gEGF has the potential to enhance growth performance, improve immune function, and promote intestinal development in broiler chickens. Keywords: gallus epidermal growth factor, Lactococcus lactis, broiler chickens, growth performance, immune function, intestinal development 3 Background Epidermal growth factor (EGF) is a small polypeptide that can promote cell proliferation and differentiation [1]. EGF has been shown to play an important role in gastrointestinal repair [2], gastric acid secretion [3], the regulation of embryo development [4,5], and the regulation of ion transport [6,7].…”

“…Keywords: gallus epidermal growth factor, Lactococcus lactis, broiler chickens, growth performance, immune function, intestinal development 3 Background Epidermal growth factor (EGF) is a small polypeptide that can promote cell proliferation and differentiation [1]. EGF has been shown to play an important role in gastrointestinal repair [2], gastric acid secretion [3], the regulation of embryo development [4,5], and the regulation of ion transport [6,7]. Recent studies have shown that EGF and EGFR may also be involved in tumorigenesis [8,9], and EGFR has been utilized as a target for cancer therapy.…”