Transforming growth factor‐β1 gene expression and cyclosporine A‐induced gingival overgrowth: a pilot study

Abstract

Lower level TGF-beta1 gene expression, not functional polymorphism, in patients treated with CsA may be considered to be a risk factor for GO.

TGF‐β1 gene polymorphism in renal transplant patients with and without gingival overgrowth

“…Having in mind the power of the study, the present report seems to be most reliable in comparison with the further studies. The results of the present study are in line with the report of Radwan‐Oczko et al (2008) demonstrating no association of the coding region polymorphisms of TGFB1 gene and gingival overgrowth, contrary to studies of Linden et al , 2001 and Radwan‐Oczko et al , 2006. The present study was extended to functional polymorphisms located in promoter region of the TGFB1 gene, and similarly to results from coding regions any associations of genetic factors with gingival overgrowth in kidney transplant patients were revealed.…”

“…Therefore, it was decided to evaluate TGFB1 gene polymorphism in kidney transplant patients medicated with cyclosporine A. Former studies included polymorphisms in the coding regions of the gene resulting in aminoacid substitutions, namely in codon 10 ‐ +869T>C Pro10Leu and codon 25 + 915G>C Arg25Pro (Linden et al , 2001; Radwan‐Oczko et al , 2006, 2008). However, it is well known that polymorphisms located in promoter region of the gene can also be functional, affecting expression level of genes; hence in the present study, polymorphisms in the promoter of TGFB1 gene were evaluated at positions −800G>A and −509C>T (Grigner et al , 1999; Grainger et al , 2000).…”

“…Previous reports, similar to our report, included patients from Caucasian populations, but number of cases analysed was smaller than in the present study. Study by Linden et al (2001) involved 164 kidney transplant patients medicated with cyclosporin A (46 with gingival overgrowth), by Radwan‐Oczko et al , 2006 comprised 92 subjects (50 with gingival overgrowth) and Radwan‐Oczko et al , 2008; included 98 subjects (of them 54 with gingival overgrowth). The present study involved 224 patients, including 84 with gingival overgrowth.…”

“…codon 10 -+869T>C Pro10Leu and codon 25 + 915G>C Arg25Pro are genetic factors associated with risk of gingival overgrowth. A subsequent report from the latter group (Radwan-Oczko et al, 2008) showed that the aforementioned polymorphisms are not associated with gingival overgrowth observer in kidney transplant patients medicated with cyclosporin A. Therefore, it was decided to evaluate TGFB1 gene polymorphism in kidney transplant patients medicated with cyclosporine A.…”

“…Clinical studies in kidney transplant patients medicated with cyclosporine A suggested an association between TGFB1 gene polymorphism located in coding regions (codon 10 ‐ +869T>C Pro10Leu and codon 25 + 915G>C Arg25Pro) and gingival overgrowth (Linden et al , 2001; Radwan‐Oczko et al , 2006). However, contradictory results in kidney transplant patients with respect to the same as aforementioned SNPs are also available (Radwan‐Oczko et al , 2008).…”