Transforming growth factor beta and bone morphogenetic protein 2 for bone ingrowth: A comparison using bone chambers in rats

Aspenberg, Per; Jeppsson, Charlotte; Wang, J.-S.; Bostrom, Mathias P.

doi:10.1016/s8756-3282(96)90257-4

Cited by 61 publications

(30 citation statements)

References 11 publications

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“…Furthermore, the inhibition is not a specific BMP-2 effect or dependent on the formulation we used, because it was also found when OP-1 was placed in the bone harvest chamber. Moreover, as BMP-2 on hydroxyapatite has been shown to enhance bone formation in the rat chamber model (Aspenberg et al 1996a), it is unlikely that the carrier is responsible for the negative effect on bone formation in the bone harvest chamber in rabbits.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, BMP-2 from the same batch on the same canier was implanted in a different type of chamber in rats. This model has previously shown increased bone formation in response to BMP-2 on a hydroxyapatite carrier (Aspenberg et al 1996a), and served as a positive control to exclude defects of the BMP-2-collagen implant.…”

Section: Charlotte Jeppsson' Mathias Bostrom2 and Per Aspenberglmentioning

confidence: 99%

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Intraosseous BMP implants in rabbits Inhibitory effect on bone formation

Jeppsson

Bostrom

Aspenberg

1999

Acta Orthopaedica Scandinavica

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Section: Discussionmentioning

confidence: 99%

Section: Charlotte Jeppsson' Mathias Bostrom2 and Per Aspenberglmentioning

confidence: 99%

Intraosseous BMP implants in rabbits Inhibitory effect on bone formation

Jeppsson

Bostrom

Aspenberg

1999

Acta Orthopaedica Scandinavica

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“…Recently, the function of individual BMPs on various cell types, cultured with various biomaterials has been extensively tested44, 102,113,125,170,171,176,177). In vivo experiments surprisingly showed that BMP-2 (probably model-related) can inhibit176) or increase125) bone ingrowth.…”

Section: Genetic Potential Of Osteopromotive Growth Factors On Implanmentioning

confidence: 99%

Genetic Potential of Interfacial Guided Osteogenesis in Implant Devices.

Letic-Gavrilovic

Scandurra

Abe

2000

Dental Materials Journal

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“…Other preclinical studies have shown inhibition of osteogenic proliferation and differentiation as well as reduction of the activity of demineralized bone matrix, leading to a decrease of bone formation [3,4,7,10,11,33].…”

Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma in mono-segmental posterior lumbar interbody fusion

et al. 2011

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Introduction The results of platelet-rich plasma (PRP) in spinal fusion applications are limited and controversial. Both beneficial and inhibitory effects have been shown. In this prospective randomised controlled trial, our objective was to assess both the clinical and radiologicaleffect of PRP when added to autograft iliac crest bone in posterior lumbar interbody fusion. Methods and materials Forty patients were recruited for the study fulfilling strict entry requirements and were randomised with a 1:1 ratio. In each group, one patient was lost to follow-up. Thirtyeight patients completed the Visual Analogue Scale (VAS), the Oswestry Disability Index (ODI), and the Short-Form 36 (SF-36) preoperatively and postoperatively at 3, 6, 12, and 24 months, respectively. CT-scans of the lumbar spine were taken at 3, 6, and 12 months. Posterior stabilisation was achieved with pedicle screws and interbody fusion was aimed at with carbon cages filled with autologous bone. Results Baseline demographic data (age, sex, smoking history, preoperative outcome measures) showed no relevant difference between groups. For patients who received autograft only, the mean VAS improved by 4.0 points (p \ 0.01), mean ODI improved by 32.1 points (p \ 0.001), and mean SF-36 showed statistically significant improvement in each of the eight domains and in the physical (p \ 0.001) and mental (p \ 0.001) component summary measures. For patients who received autograft with PRP, the mean VAS improved by 4.92 points (p \ 0.01), mean ODI improved by 30 points (p \ 0.001), and mean SF-36 showed statistically significant improvement in six of the eight domains (p \ 0.02) and in the physical (p = 0.016) and mental (p \ 0.001) component summary measures. The improvement of the VAS score and the physical component summary score was more pronounced in patients who received autograft with PRP. These differences were, however, not statistically significant. CT-scans showed uneventful osseous healing in all but one patient with no difference between groups. Conclusion In this prospective randomised controlled clinical and radiological trial, adding PRP in posterior lumbar interbody fusion did not lead to a substantial improvement or deterioration when compared with autologous bone only. No inhibitory effect of PRP was observed on CT-scans. From a clinical and radiological point of view, the use of PRP seems to be justified in posterior lumbar interbody fusion surgery. From an economical point of view, the expense of using PRP cannot be justified until statistical significance can be reached in a larger study.

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Transforming growth factor beta and bone morphogenetic protein 2 for bone ingrowth: A comparison using bone chambers in rats

Cited by 61 publications

References 11 publications

Intraosseous BMP implants in rabbits Inhibitory effect on bone formation

Intraosseous BMP implants in rabbits Inhibitory effect on bone formation

Genetic Potential of Interfacial Guided Osteogenesis in Implant Devices.

Platelet-rich plasma in mono-segmental posterior lumbar interbody fusion

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