Transforming Growth Factor Beta-1 C-509T Polymorphism and Cancer Risk: A Meta-analysis of 55 Case-control Studies

Liu, Yang; Xin, Lin; Cui, Lin; Jin, Sisi; Wu, Jin-Ming

doi:10.7314/apjcp.2012.13.9.4683

Cited by 17 publications

(15 citation statements)

References 56 publications

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Section: Discussionsupporting

confidence: 82%

“…Previous meta-analyses on this topic have yielded conflicting results [28][29][30][31][32]. The results of metaanalyses by Xiang et al [28], Liu et al [30], and Li et al [31] were similar to ours. However, a meta-analysis by Zhang et al [29] reported a significant association between TGF-β1 C-509T variants and decreased HCC susceptibility, and another meta-analysis by Guo et al [32] demonstrated a close association between TGF-β1 C-509T variants and increased HCC susceptibility.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Association between transforming growth factor-β1 -509 C>T variants and hepatocellular carcinoma susceptibility: a meta-analysis

Toshikuni¹,

Matsue²,

Minato³

et al. 2016

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The transcriptional activity of transforming growth factor-β (TGF-β) is increased in subjects with hepatocellular carcinoma (HCC). Recent studies have indicated that the -509C genotype in hepatitis B virus (HBV)-infected subjects and the -509T genotype in hepatitis C virus (HCV)-infected subjects can increase the transcriptional activity of the TGF-β1 gene. We conducted a meta-analysis to clarify whether these two hepatitis viruses affect the association between TGF-β1 C-509T variants and HCC susceptibility. Using data derived from 8 case-control studies available in the PubMed database (5 with Asian and 3 with Caucasian populations), including 1,427 cases and 3,735 controls [1,610 patients with chronic liver disease and 2,125 healthy controls], we calculated pooled odds ratios with corresponding 95% confidence intervals. We used dominant (TT + CT vs. CC), recessive (TT vs. CC + CT), and co-dominant (TT vs. CC and CT vs. CC) genetic models. An overall analysis showed no association between the TGF-β1 C-509T variants and HCC susceptibility for all models. In contrast, a subgroup analysis, based on the infecting hepatitis viruses, provided the following results. Among the cases and controls with chronic liver disease, the TGF-β1 C-509T variants were significantly associated with decreased HCC susceptibility for two models with HBV-infected subjects, whereas the variants were significantly associated with increased HCC susceptibility for one model with HCV-infected subjects. Among the cases and healthy controls, there was a significant association between the TGF-β1 C-509T variants and increased HCC susceptibility for two models involving HCV-infected subjects. Among the cases and the entire control group, the same results were obtained for all genetic models with HCV-infected subjects. Although further data accumulation is required, our results suggest that these two hepatitis viruses affect the association between TGF-β1 C-509T variants and HCC susceptibility in opposite manners.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 82%

Association between transforming growth factor-β1 -509 C>T variants and hepatocellular carcinoma susceptibility: a meta-analysis

Toshikuni¹,

Matsue²,

Minato³

et al. 2016

neo

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“…Similarly, recent case-control study as well as metaanalysis have shown no association of TGF β1 -509T*C with the risk of hepatocellular carcinoma or overall cancer risk (Liu et al, 2012;Shi et al, 2012). However, some studies have reported that TGF-β1 *29C was protective against breast cancer and suggested that *29C is a protective allele and *29T a risk allele by showing that the individuals with C/C genotype had a significantly lower risk of developing breast cancer compared to those with the T/T or T/C genotype (Ziv et al, 2001;Hishida et al, 2003;Joshi et al, 2011).…”

Section: Discussionmentioning

confidence: 94%

No Association of the TGF-β1 29T/C Polymorphism with Breast Cancer Risk in Caucasian and Asian Populations: Evidence from a Meta-Analysis Involving 55, 841 Subjects

Alqumber¹,

Dar²,

Haque³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The transforming growth factor-β1 (TGF-β1) gene 29 T/C polymorphism is thought to be associated with breast cancer risk. However, reports are largely conflicting and underpowered. We therefore conducted a metaanalysis of all available case-control studies relating the TGF-β1 29T/C polymorphism to the risk of developing breast cancer by including a total of 31 articles involving 24,021 cases and 31,820 controls. Pooled ORs were generated for the allele contrasts, with additive genetic, dominant genetic and recessive genetic models. Subgroup

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“…Recently, several groups have used meta-analysis to investigate the association between cancer risk and gene Single nucleotide polymorphisms (SNP) involved in TGF-β signaling (Huang et al, 2010;Huang et al, 2011;Liu et al, 2012). As one of the key effectors of TGF-β signaling, TGFBR2 mediates the growth-inhibitory signals from TGF-β through a complex with TGFBR1 (Derynck and Zhang, 2003;Ikushima and Miyazono, 2010).…”

Section: Discussionmentioning

confidence: 99%

Association between the TGFBR2 G-875A Polymorphism and Cancer Risk: Evidence from a Meta-analysis

Huang¹,

Zhong²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Transforming Growth Factor Beta-1 C-509T Polymorphism and Cancer Risk: A Meta-analysis of 55 Case-control Studies

Cited by 17 publications

References 56 publications

Association between transforming growth factor-β1 -509 C>T variants and hepatocellular carcinoma susceptibility: a meta-analysis

Association between transforming growth factor-β1 -509 C>T variants and hepatocellular carcinoma susceptibility: a meta-analysis

No Association of the TGF-β1 29T/C Polymorphism with Breast Cancer Risk in Caucasian and Asian Populations: Evidence from a Meta-Analysis Involving 55, 841 Subjects

Association between the TGFBR2 G-875A Polymorphism and Cancer Risk: Evidence from a Meta-analysis

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