Transformations of organic compounds under the action of mechanical stress

The peculiarities of transformation of organosilicon polymer into ceramic products under mechanochemical treatment

“…10 One of these groups comprises the processes of conformational transformation, disordering and amorphization of crystalline structure which are generated by split of intermolecular bonds. Another group presents mechanochemical reactions initiated by deformation of valence angles and bonds.…”

“…One can expect that the combination of mechanical effects on organosilicon polymers will also induce chemical and structural changes and result in the formation new phases. Mechanical destruction of organosilicon polymers, especially, polysiloxanes was studied by Dubinskaya 10 and Balykova and Rode. 11 It was found that the mechanical effects induced radical chain scissions within polymer molecules and breaking of intermolecular bonds.…”

Mechanochemistry in heterogeneous catalysis

“…Examples of the use of stoichiometric mechanically activated processes in fine organic synthesis were recently examined in the extensive review articles [2,12]. We will restrict ourselves to the use of reactions in the catalytic regime, where it is not the reagents that are activated but the catalyst.…”

Complexes of Polysaccharides and Glycyrrhizic Acid with Drug Molecules − Mechanochemical Synthesis and Pharmacological Activity

“…This difficulty may be surmountable with solid-state chemistry approaches, specifically, with mechanochemical transformations in mixtures of solids [9][10][11]. Unlike the liquid-phase synthesis, mechanochemical treatment is a simpler single-stage process going without solvents or melts and respective additional procedures.…”

“…The mixtures of powdered components (polysaccharides/complexing agents and drugs) were dispersed in ball mills at greater or lower intensities in laboratory planetary-and rotary-type mills, respectively. Milder rotary milling was predominantly applied because the molecular-level mixing in a planetary mill, common to laboratory studies of mechanochemical modification of drugs [9], may partly destroy the material and pose scaling problems. The materials processed by nondestructive rotary milling [10,11,21], instead, interact to produce solid dispersed systems of components (composite aggregates of superdispersed particles), and the process is easily scaled onto industrial flow mills.…”