Transformation products of 1,1-dimethylhydrazine and their distribution in soils of fall places of rocket carriers in Central Kazakhstan

Kenessov, Bulat; Alimzhanova, Mereke; Sailaukhanuly, Yerbolat; Baimatova, Nassiba; Аbilev, Мadi; Batyrbekova, Svetlana; Carlsen, Lars; Tulegenov, Akyl; Nauryzbayev, Mikhail

doi:10.1016/j.scitotenv.2012.04.017

Cited by 59 publications

(32 citation statements)

References 12 publications

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“…For TMTZ, the limit of quantification in the water sample was 9 and 90 ng/mL using an amperometric and spectrophotometric detector, respectively [8]. Another study based on headspace SPME-GC-MS apparatus was developed for the screening of transformation products from soil and water samples [7,11]. The present assay is the first one describing the quantification of TMTZ in biological media.…”

Section: Discussionmentioning

confidence: 98%

“…TMTZ was clearly identified in laboratory samples [7]. However, due to its volatility, TMTZ could only be detected in ground samples if sampling was performed immediately after spillage of UDMH [7].…”

Section: Introductionmentioning

confidence: 96%

“…TMTZ was also detected among the numerous compounds formed from the decomposition of UDMH, a widely used rocket propellant [4,6,7]. Possible atmospheric dispersion of UDMH and various decomposition products was studied using an in silico approach and also after analysis of soil samples [4,7]. TMTZ was clearly identified in laboratory samples [7].…”

Section: Introductionmentioning

confidence: 98%

“…These investigations result in the identification of (E)-1,1,4,4-tetramethyl-2-tetrazene (TMTZ) as a storable liquid fuel which could be considered as a new potential relevant propellant for space propulsion [5]. TMTZ was also detected among the numerous compounds formed from the decomposition of UDMH, a widely used rocket propellant [4,6,7]. Possible atmospheric dispersion of UDMH and various decomposition products was studied using an in silico approach and also after analysis of soil samples [4,7].…”

Section: Introductionmentioning

confidence: 99%

“…Possible atmospheric dispersion of UDMH and various decomposition products was studied using an in silico approach and also after analysis of soil samples [4,7]. TMTZ was clearly identified in laboratory samples [7]. However, due to its volatility, TMTZ could only be detected in ground samples if sampling was performed immediately after spillage of UDMH [7].…”

Section: Introductionmentioning

confidence: 99%

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Quantification and kinetic study in plasma and tissues of (E)-1,1,4,4-tetramethyl-2-tetrazene, a liquid propellant and a transformation product of 1,1-dimethyl hydrazine

et al. 2015

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(E)-1,1,4,4-tetramethyl-2-tetrazene (TMTZ) is formed from the oxidation of the unsymmetrical 1,1-dimethylhydrazine (UDMH) and is used as a storable liquid fuel which can be considered as a new potential propellant for space rocket propulsion. To better understand the toxicological behavior of the compound, an intraperitoneal administration of TMTZ was performed in mice to define its toxicokinetics and tissue distribution. A fully validated liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) assay was developed to determine TMTZ levels in biological samples. Determination of TMTZ was achieved using 50 μL of plasma or tissue solution. Precipitation with ammonium sulfate and acetonitrile was used for sample preparation. Liquid chromatography was performed on an Atlantis HILIC Silica column (Waters; 3 μm, 150 mm × 2.1 mm i.d.). Isocratic elution with a mixture of ammonium acetate buffer (pH 5, 100 mM)/water/acetonitrile (3:2:95, v/v/v) was used. The detection was conducted using an electrospray source in positive ion mode. TMTZ and (15)N2-TMTZ (internal standard) were quantitated in selected reaction monitoring mode using the transition m/z 117→72 and 119→74, respectively. Standard curves exhibited excellent linearity in the range of 10-500 ng/mL for plasma and 50-2000 ng/mL for all tissues (heart, liver, brain, kidney, and lung) analyzed, and acceptable precision and accuracy (<10 %) were obtained. The elimination rate constant strongly suggests that TMTZ was very quickly eliminated from the body. The results of tissue distribution experiments indicated that TMTZ underwent a rapid distribution into limited organs such as the liver, kidney, and brain.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Quantification and kinetic study in plasma and tissues of (E)-1,1,4,4-tetramethyl-2-tetrazene, a liquid propellant and a transformation product of 1,1-dimethyl hydrazine

et al. 2015

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Bioremediation

Prince¹

2019

Kirk-Othmer Encyclopedia of Chemical Technology

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Bioremediation is the process of thoughtfully exploiting biological processes to minimize an unwanted environmental impact; usually the aim is the removal of a contaminant from the biosphere. Like most definitions in biology, that of bioremediation is the subject of some debate. A narrow definition might focus on the conversion of contaminating organic molecules to CO 2 , water, and inorganic ions, and the oxidation or reduction of contaminating inorganic ions such as nitrate or ammonia to harmless forms, in this case nitrogen gas. A broader definition would include biological processes for ameliorating extremes of pH, concentrating contaminants so that they can be more easily removed by physical techniques, converting toxic species to less toxic or less bioavailable forms that pose less of a threat to the environment, and restoring functional ecosystems to contaminated or disturbed sites when the contaminants or disturbance cannot be removed.

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Identification (Quantitative Determination and Detection) and Fate of Transformation Products of Rocket Fuel 1,1‐Dimethylhydrazine

Kenessov

Carlsen²

2014

Transformation Products of Emerging Contaminants in the Environment

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Transformation products of 1,1-dimethylhydrazine and their distribution in soils of fall places of rocket carriers in Central Kazakhstan

Cited by 59 publications

References 12 publications

Quantification and kinetic study in plasma and tissues of (E)-1,1,4,4-tetramethyl-2-tetrazene, a liquid propellant and a transformation product of 1,1-dimethyl hydrazine

Quantification and kinetic study in plasma and tissues of (E)-1,1,4,4-tetramethyl-2-tetrazene, a liquid propellant and a transformation product of 1,1-dimethyl hydrazine

Bioremediation

Identification (Quantitative Determination and Detection) and Fate of Transformation Products of Rocket Fuel 1,1‐Dimethylhydrazine

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