Transformation of thiols to disulfides by epolactaene and its derivatives

Kuramochi, Kouji; Sunoki, Takashi; Tsubaki, Kazunori; Mizushina, Yoshiyuki; Sakaguchi, Kengo; Sugawara, Fumio; Ikekita, Masahiko; Kobayashi, Susumu

doi:10.1016/j.bmc.2011.06.015

Cited by 8 publications

(7 citation statements)

References 41 publications

(34 reference statements)

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“…145 Recently, Kuramochi reported disulfide formation via reactions of epolactaene with several thiols. 146 Given the crucial role of disulfide bridges in stabilizing protein structures and hence in protein function, epolactaene could be a promising new drug.…”

Section: Zg-1494 Alpha and Talaroconvolutin Thanks Tomentioning

confidence: 99%

Biologically active γ-lactams: synthesis and natural sources

2016

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The γ-lactam moiety is present in a large number of natural and non-natural biologically active compounds. The range of biological activities covered by these compounds is very broad. Functionalized γ-lactams are thus of high interest and have great potential in medicinal chemistry. This review provides a description of the title compounds by focusing on their synthesis, natural sources and biological activities.

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Section: Zg-1494 Alpha and Talaroconvolutin Thanks Tomentioning

confidence: 99%

Biologically active γ-lactams: synthesis and natural sources

2016

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“…We found recently that 1 and its derivatives induced disulfide formation of N-acetylcysteine methyl ester, suggesting that they might induce intramolecular or intermolecular disulfide formation between protein cysteines. 30,32) II. Neoechinulin A Neoechinulin A (25), an indole alkaloid, has been isolated from Aspergillus sp., [33][34][35][36][37][38][39][40][41][42] ascomysete Xylaria eulossa, 43) endophytic fungus Chaetomium globosum,…”

Section: Synthesis Of Epolactaenementioning

confidence: 99%

Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products

Kuramochi

2013

Bioscience, Biotechnology, and Biochemistry

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“…Indeed, a recent study on the reaction mechanism of epolactaene with a series of thiols (R'SH), including free (non proteinic) cysteine, evidenced the active site of epolactaene and pointed out its ability to promote disulfide formation (Fig. 4.8) [136]. Current studies from our group are examining the mechanism of action of epolactaene (9) in the HSP60 assembly using both computational and experimental approaches.…”

Section: Hsp60 Inhibitors and Their Potential Applications In Alzheimmentioning

confidence: 96%