Transformation of the Ancestral Body Plan and Axial Growth in Echinoderms: Ontogenetic and Paleontological Data

Isaeva, V. V.; Рожнов, С. В.

doi:10.1134/s0031030122080032

Cited by 7 publications

(1 citation statement)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, the gene regulatory network (and transcription factors regulating skeletogenesis have been characterized (e.g. Davidson The development of adult skeleton in a coelom or rudiment adjacent to the gut appears to be an ancient and conserved component of echinoderm development (Isaeva & Rozhnov, 2022;Mooi & David, 1998) and is considered a shared characteristic of all extant echinoderms. In contrast, larval skeletogenesis is likely a synapomorphy of holothuroids (sea cucumbers), echinoids (sea urchins), and ophiuroids (brittle stars) (Fig.…”

Section: Introductionmentioning

confidence: 99%

Shared regulatory function of non-genomic thyroid hormone signaling in echinoderm skeletogenesis

Taylor,

Heyland

2024

Preprint

View full text Add to dashboard Cite

Thyroid hormones are crucial regulators of metamorphosis and development in bilaterians, particularly in chordate deuterostomes. Recent evidence suggests a role for thyroid hormone signaling, principally via 3,5,3',5'-Tetraiodo-L-thyronine (T4), in the regulation of metamorphosis, programmed cell death and skeletogenesis in echinoids (sea urchins and sand dollars) and sea stars. Here we test whether TH signaling in skeletogenesis is a shared trait of Echinozoa (Echinoida and Holothouroida) and Asterozoa (Ophiourida and Asteroida). We demonstrate dramatic acceleration of skeletogenesis in three classes of echinoderms: sea urchins, sea stars, and brittle stars (echinoids, asteroids, and ophiuroids). Fluorescently labeled thyroid hormone analogues reveal thyroid hormone binding to cells proximal to regions of skeletogenesis in the gut and juvenile rudiment. Immunohistochemistry of phosphorylated MAPK in the presence and absence of TH binding inhibitors suggests that THs may act via phosphorylation of MAPK (ERK1/2) to accelerate skeletogenesis in the three echinoderm groups. Additionally, we detect thyroid hormone binding to the cell membrane and nucleus during metamorphic development in echinoderms. Together, these results indicate that TH regulation of mesenchyme cell activity via integrin-mediated MAPK signaling may be a conserved mechanism for the regulation of skeletogenesis in echinoderm development. Additionally, TH action via a nuclear thyroid hormone receptor may regulate metamorphic development. Our findings shed light on potentially ancient pathways of thyroid hormone activity in echinoids, ophiuroids, and asteroids, or on a signaling system that has been repeatedly co-opted to coordinate metamorphic development in bilaterians.

show abstract

Section: Introductionmentioning

confidence: 99%

Shared regulatory function of non-genomic thyroid hormone signaling in echinoderm skeletogenesis

Taylor,

Heyland

2024

Preprint

View full text Add to dashboard Cite

show abstract

The Metameric Echinoderm

Turner

2024

Integrative Organismal Biology

View full text Add to dashboard Cite

Animal phyla are distinguished by their body plans, the ways in which their bodies are organized. A distinction is made, for example, among phyla with bodies of many segments (metameric; e.g., annelids, arthropods, chordates), others with completely unsegmented bodies (americ; e.g., flatworms, mollusks), and a few phyla with bodies of two or three regions (oligomeric; e.g., echinoderms, hemichordates). The conventional view of echinoderms as oligomeric coelomates adequately considers early development, but it fails to recognize the metameric body plan that develops in the juvenile rudiment and progresses during indeterminate adult growth. As in the three phyla traditionally viewed to be metameric (annelids, arthropods, chordates), metamery, or metamerism, in echinoderms occurs by (1) subterminal budding of (2) serially repeated components of (3) mesodermal origin. A major difference in most echinoderms is that metamery is expressed along multiple body axes, usually five. The view of a metameric echinoderm might invite new discussions of metazoan body plans and new approaches to the study of morphogenesis, particularly in comparative treatments with annelids, arthropods, and chordates.

show abstract

Solutans (Echinoderms): Evolution Frozen between Torsion and Pentaradiality

Рожнов

2022

Paleontol. J.

View full text Add to dashboard Cite

Transformation of the Ancestral Body Plan and Axial Growth in Echinoderms: Ontogenetic and Paleontological Data

Cited by 7 publications

References 128 publications

Shared regulatory function of non-genomic thyroid hormone signaling in echinoderm skeletogenesis

Shared regulatory function of non-genomic thyroid hormone signaling in echinoderm skeletogenesis

The Metameric Echinoderm

Solutans (Echinoderms): Evolution Frozen between Torsion and Pentaradiality

Contact Info

Product

Resources

About