Transformation of primary myelofibrosis into acute myeloblastic leukemia: clinical case
Serik Baidurin,
Farida Bekenova,
Viktor Tkachev
et al.
Abstract:Primary myelofibrosis (PMF) is a disease from the group of Ph–negative myeloproliferative tumors, which is characterized by bone marrow fibrosis, splenomegaly and extramedullary hematopoiesis. The mean life in PMF ranges from 7.6 to 10 years and varies widely depending on the appearance of additional mutations and a higher degree of malignancy. Most patients have an indolent flow, and in some patients with PMF, the disease progresses rapidly with the development of acute myeloblastic leukemia. The internationa… Show more
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