“…The water-soluble products formed by cells (64, 310), although chemically uncharacteritied, are likely to be either sulfate, glutathione, or glucuronide conjugates. Some of these reactions form metabolic intermediates that bind convalently to DNA and RNA (3,11-15, 29,33,34,53,59,61,67,77,80,81,84,94,96,130-133,137-139,142,143, 159, 165-168,172,201-203,212,235,239,242,247,249-252,274,278,283,286, 291, [300][301][302]331) and have a variety of biological activities that include cytotoxicity (183,317,318,323), mutagenicity (5, 68, 119-121, 124, 125, 187, 188, 190-193, 196,209,210, 225,226, 254,279, 280,317,323), cell transformation in vitro (41,119,184,(192)(193)(194)(195), and cancer induction in experimental animals (36, 44,84,146,148,163,[175][176][177][178].…”