Transformation of human chondrocytes with copper-containing metal-organic biohybrids (MOBs)
Tasneem Khasru,
Katie McKenzie,
Kyle Rugg
et al.
Abstract:Copper is involved in the biosynthesis of collagen, however soluble copper salts dissipate quickly and copper nanoparticles are cytotoxic. Here we added a novel copper-containing nanomaterial (CuHARS) to assess human chondrocyte function in the presence of copper. Human dermal fibroblasts (HDFs) were also treated as a control. Chondrocyte response to CuHARS was assessed by chronic nanomaterial treatment (30 ug/ml) followed by digital microscopy and image analysis of cellular features compared to normal chondro… Show more
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