Transformation of hairy cell leukemia to high-grade lymphoma: A case report and review of the literature

Sun, Tsieh; Grupka, Nichon L.; Klein, Catherine

doi:10.1016/j.humpath.2004.08.016

Cited by 13 publications

(7 citation statements)

References 12 publications

(9 reference statements)

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“…Transformations of CLL to B cell lymphoproliferative disorders such as large cell lymphoma and prolymphocytic leukemia are a well-recognized phenomenon. Similarly, there is also evidence that HCL can also evolve into higher grade lymphoma, much like the Richter’s transformation seen among patients with CLL (18). Patients with CLL have impaired immune surveillance that makes them prone to develop second neoplasms.…”

Section: Discussionmentioning

confidence: 98%

Synchronous or Metachronous Hairy Cell Leukemia and Chronic Lymphocytic Leukemia: A Case Series and Literature Review

et al. 2017

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IntroductionConcurrent hairy cell leukemia (HCL) and chronic lymphocytic leukemia (CLL) is rare; management is inadequately described in the literature.MethodsRetrospective chart review and clinical follow-up.ResultsFive patients are described. The first patient developed synchronous HCL and CLL and was treated with rituximab for 13 months with HCL in remission and stable CLL. The second patient developed HCL and was treated with cladribine. His disease recurred 7 years later which was retreated with cladribine. Seven years later, he developed asymptomatic CLL. The third patient developed CLL, managed expectantly, then developed HCL 10 months later, and was treated with cladribine. Although his HCL went into remission, there was a slow redevelopment of CLL for which expectant management was done. The fourth patient developed concurrent CLL and HCL, received cladribine, with subsequent development of worsening abdominal lymphadenopathy and was lost to follow-up. The last patient developed concurrent HCL and CLL and was also diagnosed with lung adenocarcinoma; this patient was also lost to follow-up.ConclusionThe development of concurrent HCL and CLL may indicate a common origin. Patients with HCL may subsequently develop CLL, thus mimicking a relapse of HCL. Therapy requires individualized approach including watchful waiting in asymptomatic cases. Rituximab may be useful to treat both disorders simultaneously.

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Section: Discussionmentioning

confidence: 98%

Synchronous or Metachronous Hairy Cell Leukemia and Chronic Lymphocytic Leukemia: A Case Series and Literature Review

et al. 2017

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“…, 2003; Bhargava et al. , 2004; Sun, Grupka & Klein, 2004). Most of these reports are inconclusive regarding the question, whether the large cell lymphomas represent a blastic transformation of hairy cells, similar to the process referred to as Richter transformation in chronic lymphocytic leukemia (Armitage, Dick & Corder, 1978; Foucar & Rydell, 1980), or rather an unrelated second malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…, 2003; Bhargava et al. , 2004; Sun, Grupka & Klein, 2004), but this observation might as well simply reflect the better prognosis of HCL with longer overall survival.…”

Section: Discussionmentioning

confidence: 99%

“…Only four reports provide valid data that specifically examine the etiology of the large cell lymphomas, but the results are contradictory: while one study demonstrates different clonal origins based on different heavy‐chain and kappa‐light chain rearrangements in the two malignancies (Downing et al. , 1986), three other reports suggest a HCL origin of the large cell lymphoma, based on identical immunophenotypes of the neoplastic cells (Sun, Grupka & Klein, 2004), occurrence of identical heavy‐chain rearrangements in HCL and lymphoma cells (Friedline, Crisan & Chen, 1998) or presence of monoclonal EBV genome in the leukemic cells (Bhargava et al. , 2004), respectively.…”

Section: Discussionmentioning

confidence: 99%

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Partial remission of a newly diagnosed diffuse large B‐cell non‐Hodgkin's lymphoma in a hemodialysis patient after administration of immuno‐chemotherapy with rituximab‐CHOP

Feldmann¹,

Nattermann²,

Gerhardt³

et al. 2007

Int J Lab Hematology

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Summary To date little data exist about treatment of hematologic malignancies in patients with end‐stage renal disease (ESRD). While administration of immunochemotherapy comprising the CD20‐antibody rituximab is a well‐established treatment strategy in patients with normal renal function, little information on safety and efficacy is available in the setting of ESRD. Here we describe for the first time a hemodialysis patient suffering from diffuse large B‐cell Non‐Hodgkin's lymphoma (DLBCL) who was treated with polychemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone) in combination with rituximab (R‐CHOP). We observed no major adverse events and treatment resulted in a partial remission of the DLBCL. Thus, administration of R‐CHOP may be considered as a safe therapeutic option in this setting. Of note, this patient had a previous history of hairy cell leukemia. A review of the literature was performed and the potential etiologic link of these two B‐cell malignancies is discussed in the light of available information.

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“…Common presenting symptoms include significant anemia, which is seen in up to 85% of patients, thrombocytopenia seen in 60-80% of patients, and leukopenia seen in 60% of patients [4]. There have been several case reports associating HCL with non-Hodgkin's lymphoma [5], but the case we present here, one of aggressive blastoid non-Hodgkin's lymphoma, is very uncommon. Initial workup for HCL includes complete blood count (CBC) with differentials, platelet count, and comprehensive metabolic panel as most patients present with pancytopenia.…”

Section: Introductionmentioning

confidence: 93%

A Rare Case of a Patient With Hairy Cell Leukemia Developing Blastoid Marginal Zone B-Cell Lymphoma

Teklie¹,

Bell²,

Idogun³

et al. 2021

Cureus

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There have been several case reports associating hairy cell leukemia (HCL) with non-Hodgkin's lymphoma. However, it remains unclear whether these rare phenomena represent disease transformation or the coexistence of two separate disease entities. De novo marginal zone lymphoma can be routinely seen in elderly patients; however, in a patient with a history of HCL, a transformation is more likely than de novo blastoid marginal zone lymphoma. In this report, we present a rare case of a patient with HCL developing a high-grade blastoid marginal zone B-cell lymphoma (MZBCL).

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Transformation of hairy cell leukemia to high-grade lymphoma: A case report and review of the literature

Cited by 13 publications

References 12 publications

Synchronous or Metachronous Hairy Cell Leukemia and Chronic Lymphocytic Leukemia: A Case Series and Literature Review

Synchronous or Metachronous Hairy Cell Leukemia and Chronic Lymphocytic Leukemia: A Case Series and Literature Review

Partial remission of a newly diagnosed diffuse large B‐cell non‐Hodgkin's lymphoma in a hemodialysis patient after administration of immuno‐chemotherapy with rituximab‐CHOP

A Rare Case of a Patient With Hairy Cell Leukemia Developing Blastoid Marginal Zone B-Cell Lymphoma

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