Transformation of dihydro-1,5-benzodiazepin-2-ones under the influence of acetic anhydride

Synthesis of novel annelated systems based on the interaction and reactivity estimation of amino‐1,5‐benzodiazepin‐2‐ones with dimethyl‐2‐oxoglutaconate

“…In the 1 H NMR spectrum, the observed signals at 8.79 (pyridine ring), doublets at 8.73 and 7.91 (benzene ring), and singlets at 4.09 and 4.10 ppm (COOCH 3 groups) confirmed the presence of the 2,4‐substituted quinoline structure fragment (compare with 5g ), but there were no signals dependant on diazepine unit protons. Our early studies showed that in acidic medium the split of the N 5 C 4 bond of dihydro‐1,5‐benzodiazepinones or their transformation to a five‐membered cycle could occur [7].…”

Synthesis of 1-Acyl-3-isopropenylbenzimidazolone Derivatives and Their Activity against Botrytis cinerea

“…N -Acyl derivatives of isopropenyl benzimidazolone could be readily synthesized by the acylation of I with corresponding carboxylic acid or acyl chloride in good yields. II-1 had been reported to be synthesized using the same procedure , and it could also be prepared from 4-methyl-2,3-dihydro-1 H -1,5-benzodiazepin-2-one by acetylation in pyridine . In a program of screening antitumor compounds, II-20 was once obtained by reaction of benzoyl chloride with I , but the fungicidal activity of these two compounds was not mentioned in the references.…”