“…Recently, several typical examples of the one-pot synthesis of chiral alcohols from alkynes ( Supplementary Table S3 ) has been reported, mainly focusing on the combination of different types of hydrations and enantioselective reductions. These include the use of excess formic acid as a solvent-mediated hydration coupled with Rh-catalyzed asymmetric transfer hydrogenation (ATH), ( Li et al, 2013 ), noble metallic/ligand catalysts such as [(iPr)AuX] (X = NTf 2 or BF 4 ), ( Ye et al, 2015 ; Xia et al, 2017 ), [(iPr)AuCl], ( Li et al, 2015 ), Co-Salen ( Wang et al, 2014 ), and Co-Porphyrin ( Lu et al, 2015 ) mediated hydration coupled with Rh-catalyzed ATH, and TfOH-catalyzed hydration coupled with Rh-mediated asymmetric hydrogenation (AH) ( Liu et al, 2018a ) or ATH ( Liu et al, 2018b ). Despite the great developments that have been made in the one-pot synthesis of enantiopure alcohols from alkynes, most of the reactions should be conducted under high temperatures ( Li et al, 2013 ), high pressure, ( Liu et al, 2018a ), and/or in acidic media which require a large amount of NaOH for pH adjustment.…”