Transformation/Neodifferentiation of Human Skin Fibroblasts by Acute Oncornaviruses and Dexamethasone

Kopelovich, Levy; Fenyk, Judith

doi:10.1159/000163497

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…In principle, however, altered expression of the cancer cell phenotype, or the normal cell phenotype, by "oncogenes" is possible [45,. For example, we recently demonstrated the conversion of human SF to adipocytes and macrophages by transduction with v-rasand v-fes-derived oncogenes, respectively [48,49,53,55,56]. In this view, activation of proto-oncogenes, in at least certain instances, represents a normal physiological process.…”

Section: Epiloguementioning

confidence: 97%

Heritable colorectal cancer and cancer genes: Systemic expressions

Kopelovich

1993

Molecular Carcinogenesis

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Epidemiological studies of heritable cancer have demonstrated that cancer predisposition is a dominant trait; these studies have also predicted the recessive outcome of the neoplastic process. Biochemical studies of dominantly heritable cancer have demonstrated the relevance of systemic effects. The systemic effects are presumably due to a dominant mutation at the "initiator locus." Collectively they define cancer initiation at the cellular level (as described in this review). Molecular biological studies have demonstrated that cancer progression and the appearance of clinical cancer occur through an accumulation of recessive mutations at critical loci. We must continue to try to define not only the inherited and acquired gene defects that initiate the neoplastic state but also the subsequent genetic alterations and biomarkers involved in tumor progression. These genetic defects are already proving useful in diagnosis and prognostication. The hope is that these biomarkers may be useful for designing specific differentiation therapy.

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Section: Epiloguementioning

confidence: 97%

Heritable colorectal cancer and cancer genes: Systemic expressions

Kopelovich

1993

Molecular Carcinogenesis

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Enhancement of differentiation of cultured adipogenic cells (TA1) by pertussis toxin

Shinohara¹,

Murata²,

Shimizu³

1992

Biochem. Cell Biol.

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Differentiation of adipocytes is controlled by a variety of hormones and growth factors. To investigate the possible role of GTP-binding proteins (G proteins) in the process of adipose conversion, we studied the effect of pertussis toxin on differentiation of the fibroblast/adipocyte cell line (TA1). Pertussis toxin potentiated dexamethasone- and indomethacin-induced adipocyte differentiation in a time- and dose-dependent fashion. Addition of dibutyryl cAMP or forskolin inhibited adipose conversion, indicating that an abolishment of inhibitory control of adenylate cyclase is not responsible for the action of pertussis toxin. The B oligomer of the toxin did not mimic the effect of the holotoxin. Pertussis toxin catalyzed ADP-ribosylation of 40,000 molecular mass protein of the membrane fraction was dose-dependently inhibited by the pretreatment of the cells with the toxin. These results indicate the possible involvement of pertussis toxin-sensitive G proteins in adipogenesis.

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Transformation/Neodifferentiation of Human Skin Fibroblasts by Acute Oncornaviruses and Dexamethasone

Cited by 2 publications

References 21 publications

Heritable colorectal cancer and cancer genes: Systemic expressions

Heritable colorectal cancer and cancer genes: Systemic expressions

Enhancement of differentiation of cultured adipogenic cells (TA1) by pertussis toxin

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