Transformation gélatineuse de la moelle osseuse : une série rétrospective monocentrique de 12 cas

Chronic hip pain

“…It occurs in a wide range of underlying conditions including anorexia nervosa, malabsorption (celiac disease or inflammatory bowel disease), massive weight loss after bariatric surgery, alcoholism, advanced cancers, and chronic infections such as acquired immunodeficiency syndrome (AIDS) [1][2][3]. GMT was first identified in autopsy specimens of patients suffering from starvation which led to the alternative term Bbone marrow starvation^ [2,[4][5][6].…”

Gelatinous transformation of bone marrow

“…About 11.4% of the etiologies were represented by other causes, such as iron deficiency, renal failure, psychoses, and myelodysplastic syndrome. Etiologies mentioned by other studies2 - 6 , 8 include renal failure,3 disseminated tuberculosis, alcoholic pancreatitis,5 systemic lupus erythematosus,2 , 4 excessive physical activity,6 and non-specified eating disorders 8…”

“…The main feature is adipose cell atrophy, hematopoietic tissue hypoplasia, and the deposition of an eosinophilic substance, which consists of a material similar to mucopolysaccharide hyaluronic acid 3 - 5. This substance stains for Alcian Blue at pH 2.5, but loses its positivity after pretreatment with bovine testicular hyaluronidase 2…”

“…Other clinical scenarios are malabsorption, alcoholism,7 severe infections,3 congestive heart failure, and acute febrile states 1…”

“…The possibility of other hypotheses to explain the physiopathology of this phenomenon1 , 3 include the existence of GTBM in other diseases without the obligatory association with malnutrition, and patients with severe anorexia nervosa whose bone marrow does not develop this transformation.…”