Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy

Jiang, Yuyan; Xiao-yan, Zhao; Huang, Jiaguo; Li, Jingchao; Upputuri, Paul Kumar; Sun, He; Han, Xiao; Pramanik, Manojit; Miao, Yansong; Duan, Hongwei; Pu, Kanyi; Zhang, Ruiping

doi:10.1038/s41467-020-15730-x

Cited by 306 publications

(218 citation statements)

References 56 publications

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“…In addition, the photothermal conversion e ciency of ICG@FeDH and ICG@FeD is also calculated to be 19.7% and 19.5%, respectively ( Figure 2F and S3). The values are apparently lower than previously reported semiconducting polymeric nanoparticles (SPNs) [47,48], which is due to that the polymerization of small molecules into macromolecules can improve their optical properties [49,50]. Anyway, the results con rm that the prepared ICG@FeDH can be used as an excellent and stable photothermal agent.…”

Section: Photothermal Effect Of Icg@fedhmentioning

confidence: 58%

Hyaluronic acid modified covalent organic polymers for efficient targeted and oxygen-evolved phototherapy

Shu

Yang

Zhang

et al. 2020

Preprint

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The integration of multiple functions with organic polymers-based nanoagent holds great potential to potentiate its therapeutic efficacy, but still remains challenges. In the present study, we design and prepare an organic nanoagent with oxygen-evolved and targeted ability for improved phototherapeutic efficacy. The iron ions doped poly diaminopyridine (FeD) is prepared by oxidize polymerization and modified with hyaluronic acid (HA). The obtained FeDH appears uniform morphology and size. Its excellent colloidal stability and biocompatibility are demonstrated. Specifically, the FeDH exhibits catalase-like activity in the presence of hydrogen peroxide. After loading of photosensitizer indocyanine green (ICG), the ICG@FeDH not only demonstrates favorable photothermal effect, but also shows improved generation ability of reactive oxygen species (ROS) under near-infrared laser irradiation. Moreover, the targeted uptake of ICG@FeDH in tumor cells is directly observed. As consequence, the superior phototherapeutic efficacy of the targeted ICG@FeDH over non-targeted counterparts is also confirmed in vitro and in vivo. Hence, the results demonstrate that the developed nanoagent rationally integrates the targeted ability, oxygen-evolved capacity and combined therapy in one system, offering a new paradigm of polymer-based nanomedicine for tumor therapy.

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Section: Photothermal Effect Of Icg@fedhmentioning

confidence: 58%

Hyaluronic acid modified covalent organic polymers for efficient targeted and oxygen-evolved phototherapy

Shu

Yang

Zhang

et al. 2020

Preprint

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“…Among a variety of stimuli for remote control, light has served as a paradigm for noninvasiveness, high spatial‐temporal controllability, and low toxicity. [ 18 ] Particularly, near‐infrared (NIR) light with deep tissue penetration is favorable in various biomedical applications such as optical imaging, [ 19 ] photoregulation, [ 20 ] and phototherapy including photothermal therapy (PTT) [ 21 ] and photodynamic therapy (PDT). [ 22 ] Among various phototheranostic agents such as carbon nanotubes, [ 23 ] silica nanoparticles, [ 24 ] metal–organic framework (MOF) nanoparticles, [ 25 ] 2D materials, [ 26 ] and porphyrin nanoparticles, [ 7c,27 ] semiconducting polymer nanoparticles (SPNs) with benefits of adjustable optical properties, high biocompatibility, and high chemical flexibility have shown great potential in light‐controllable regulation of biological events.…”

Section: Figurementioning

confidence: 99%

Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

et al. 2020

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In particular, activatable immunotherapeutic nanoplatforms have received tremendous attention as these nanomedicines can exert immunotherapeutic action only in response to certain stimuli, which largely promoted the specificity and controllability of immunotherapeutic response at designated sites. [7] On account of the restricted immune cell infiltration and dysfunction of immune cells by metabolic stress, [8] modulation of cancer metabolic pathways with immunotherapeutic drugs to reprogramme the tumor immune microenvironment has emerged as a promising approach, namely, immunometabolic cancer therapy. [9] Modulation of lactic acid production, [10] inhibition of glutamine catabolism, [11] and suppression of tryptophan catabolism [12] represent some attractive targets for immunometabolic intervention and tumor suppression. Till now, several small-molecule inhibitors have been developed for immunometabolic intervention and entered clinical testing, such as navoximod (also known as NLG919), HTI-1090 (also known as SHR9146), and DN1406131. [13] However, small-molecule inhibitors are commonly unable to maintain sustainable immune response and suffer from drug resistance and some adverse side effects, which hinders their therapeutic efficacy in the modulation of immunometabolism. [14] In contrast to small-molecule inhibitors, enzyme immunotherapeutics possess highly selective capabilities in catalyzing shifts in the local availability of immunostimulatory and immunosuppressive signals. [15] Additionally, enzyme treatment eliminates immunosuppressive metabolite irrespective of different pathways and alleviates concerns of mutation and the drug resistance, thus overpassing many limitations of small-molecule inhibitors. [16] However, the clinical success of enzyme immunotherapeutics frequently hinges upon achieving sustained biocatalysis over relevant time scales at the designated site owing to rapid clearance enzyme degradation via proteases and insufficient accumulation at target tissues. [17] Therefore, the integration of enzyme immunotherapeutics with activable nanoplatforms could be a promising strategy to address these issues. Among a variety of stimuli for remote control, light has served as a paradigm for noninvasiveness, high spatial-temporal controllability, and low toxicity. [18] Particularly, near-infrared

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“…[4] Conventional antitumor therapies, for instance, chemo therapy and radiotherapy, vary in their abilities to induce ICD, and sometimes their toxicity to immune cells countervails their immune potentiation. Recently, many studies have investigated the use of nanomedicines for ICDinducing therapies that can be controlled by external sources, such as phototherapy [70,71] and fer rotherapy, [12] leading to amplified antitumor immune response. On account of prolonged circulation time, immune evasion, and inflammationtargeting ability, leukocyte membranecoated nano particles are also attractive vehicles to codeliver ICDinducing drugs and immunotherapeutic agents to realize synergistic antitumor therapy.…”

Section: Icd-inducing Taa Releasementioning

confidence: 99%

Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles

Zeng

2020

Adv Funct Materials

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130

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Cancer immunotherapy has received tremendous attention in the past decade owing to its clinical successes with the use of immune-checkpoint inhibition and chimeric antigen receptor T cell therapy. However, only a small proportion of the patients have benefited from these immunotherapeutic drugs, which has raised concerns about the low response rate and immune-related adverse events. Nanomedicines have served as a paradigm for preferential tumor accumulation but still confront issues such as poor circulation and insufficient tumor accumulation. By virtue of coating nanoparticles with cell membranes from diverse cell sources, active proteins on cell membranes can impart a variety of desired functionalities or supplementary therapeutic effects to nanoparticles, providing ways for enhanced cancer immunotherapy. In this review, the recent advances of cell membrane camouflaged nanoparticles applied to the improved immunotherapy are discussed on the basis of different sources of cell membranes and corresponding working mechanisms. These biomimetic nanoparticles can potentially deliver therapeutic agents to the designated sites and actively engage in particular stages of the cancer immunity cycle, eliciting antitumor immunity with less off-target toxicities.

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Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy

Cited by 306 publications

References 56 publications

Hyaluronic acid modified covalent organic polymers for efficient targeted and oxygen-evolved phototherapy

Hyaluronic acid modified covalent organic polymers for efficient targeted and oxygen-evolved phototherapy

Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles

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