Transform commercial magnetic materials into injectable gel for magnetic hyperthermia therapy in vivo

Xie, Guangchao; Wang, Lishi; Li, Bingjie; Zhang, Cai; Zhang, Xuejun

doi:10.1016/j.colsurfb.2023.113185

Cited by 5 publications

(3 citation statements)

References 46 publications

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Section: Magnetic Gels For Skin Cancermentioning

confidence: 99%

“…Currently, new forms of treatments are being investigated, either alone or applied in combination with those mentioned above, that aim to aid the healing process when the diseased tissue is removed [27,61,63,69]. Among the new strategies proposed is the use of magnetic gels that aim to alleviate the side effects of treatments (Figure 3), providing specificity directed at the injured tissue, and greater effectiveness and safety [69]. However, one of the main difficulties encountered when using these systems is inability of MNPs to penetrate due to the barrier function of the skin, although the barrier is partially broken in lesions or during inflammatory episodes, as in the case of skin cancer [34].…”

Section: Magnetic Gels For Skin Cancermentioning

confidence: 99%

“…In addition, we found that several works are seeking the development of magnetic gels in order to treat other types of cancer. For example, Xie and coworkers [69] developed injectable magnetic gels using commercial chemicals for application in the magnetic hyperthermia of tumors in vivo. The researchers added commercial magnetic metals (metal oxide powders) to a Ca 2+ -alginate (ALG-Ca 2+) gel.…”

Section: Magnetic Gels For Skin Cancermentioning

confidence: 99%

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Magnetic Gels in Skin Cancer Treatment: A Review of Potential Applications in Diagnostics, Drug Delivery and Hyperthermia

Bruschi

Nunes

2023

Pharmaceutics

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Skin cancer (SC) is affecting an increasing number of people worldwide. Its lesions affect mainly the most exposed regions of the skin. SC is classified into to main categories: non-melanoma (basal cell carcinoma of the epidermis and squamous cell carcinoma) and melanoma (the abnormal proliferation of melanocytes, which is rarer, more hazardous, and more deadly). Prevention and early diagnosis are important actions, and surgery is often considered. After the removal of cancerous lesions, the local administration of medicine can guarantee anticancer therapeutic action, rapid healing and the recovery of tissue, ensuring the absence of recurrence. Magnetic gels (MGs) have attracted increased attention regarding their pharmaceutical and biomedical applications. They are magnetic nanoparticles (e.g., iron oxide nanoparticles) dispersed in a polymeric matrix, which constitute adaptive systems under a magnetic field. MGs can combine magnetic susceptibility, high elasticity, and softness, and are thus useful platforms for diagnostics, drug delivery, and also for hyperthermia. This manuscript reviews MGs as a technological strategy for the treatment of SC. An overview of SC and the treatment, types, and methods of preparing MGs are discussed. Moreover, the applications of MGs in SC and their future perspectives are considered. The combination of polymeric gels and magnetic nanoparticles continues to be investigated, and new products must hit the market. Clinical trials and new products are expected, due to the important advantages of MGs.

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Section: Magnetic Gels For Skin Cancermentioning

confidence: 99%

Section: Magnetic Gels For Skin Cancermentioning

confidence: 99%

Section: Magnetic Gels For Skin Cancermentioning

confidence: 99%

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Magnetic Gels in Skin Cancer Treatment: A Review of Potential Applications in Diagnostics, Drug Delivery and Hyperthermia

Bruschi

Nunes

2023

Pharmaceutics

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Achieving Complete Tumor Clearance: A Minimalist Manganese Hydrogel for Magnetic Resonance Imaging‐Guided Synergetic Microwave Ablation and Chemodynamic Therapy

Zhou,

Shu,

Luo

et al. 2024

Adv Healthcare Materials

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The combination of microwave ablation (MWA) and chemodynamic therapy (CDT) presents a promising strategy for complete eradication of residual tumor after MWA. However, it remains challenging and urgent to develop a facile, biocompatible, and imaging‐guided platform for the achievement of this goal. Herein, we propose a minimalist manganese hydrogel (ALG‐Mn hydrogel) for synergistic MWA and CDT to completely eradicate tumor in vivo. The ALG‐Mn hydrogel is prepared using a simple mixing method and exhibited excellent syringeability, remarkable microwave sensitivity, and potent Fenton‐like activity. By assisting in MWA procedures, the ALG‐Mn hydrogel enables both elimination of primary tumor mass through enhanced MWA efficacy and eradication of potential residual tumor tissues via robust CDT. This approach achieves complete tumor clearance without requiring additional drug loading. Furthermore, the paramagnetic Mn2+ component allows real‐time dynamic visualization of the ALG‐Mn hydrogel at the tumor site via magnetic resonance imaging (MRI). To our best of knowledge, the proposed ALG‐Mn hydrogel represents the minimalist biocompatible platform for imaging‐guided synergistic MWA and CDT towards achieving complete tumor clearance.This article is protected by copyright. All rights reserved

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Research progress in the synthesis and application of magnetic self-healing polymer composites

Li,

Gu,

Liu

et al. 2024

European Polymer Journal

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Transform commercial magnetic materials into injectable gel for magnetic hyperthermia therapy in vivo

Cited by 5 publications

References 46 publications

Magnetic Gels in Skin Cancer Treatment: A Review of Potential Applications in Diagnostics, Drug Delivery and Hyperthermia

Magnetic Gels in Skin Cancer Treatment: A Review of Potential Applications in Diagnostics, Drug Delivery and Hyperthermia

Achieving Complete Tumor Clearance: A Minimalist Manganese Hydrogel for Magnetic Resonance Imaging‐Guided Synergetic Microwave Ablation and Chemodynamic Therapy

Research progress in the synthesis and application of magnetic self-healing polymer composites

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