Transfersome Hydrogel Containing 5-Fluorouracil and Etodolac Combination for Synergistic Oral Cancer Treatment

Bollareddy, Srivarsha Reddy; Krishna, Vandana; Roy, Girdhari; Dasari, Deepika; Dhar, Animesh; Venuganti, Venkata Vamsi Krishna

doi:10.1208/s12249-022-02221-z

Cited by 8 publications

(3 citation statements)

References 41 publications

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“…FdUTP is incorporated in the DNA causing direct damage, whereas FUTP is directly incorporated into RNA preventing pre-ribosomal RNA maturation [ 42 , 43 ]. COX-2 is associated with carcinogenesis and cancer cells resistance to therapy [ 44 ]. The combination showed synergistic effects, while increasing drug delivery to cancer cells [ 44 ].…”

Section: New Combinatorial Approaches For Oral Cancer Treatmentmentioning

confidence: 99%

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Combination Therapy as a Promising Way to Fight Oral Cancer

et al. 2023

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Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis and high mortality rates. Conventional treatment strategies, such as surgery, chemotherapy, and radiation therapy, alone or in combination, are associated with significant side effects. Currently, combination therapy has become the standard practice for the treatment of locally advanced oral cancer, emerging as an effective approach in improving outcomes. In this review, we present an in-depth analysis of the current advancements in combination therapies for oral cancer. The review explores the current therapeutic options and highlights the limitations of monotherapy approaches. It then focuses on combinatorial approaches that target microtubules, as well as various signaling pathway components implicated in oral cancer progression, namely, DNA repair players, the epidermal growth factor receptor, cyclin-dependent kinases, epigenetic readers, and immune checkpoint proteins. The review discusses the rationale behind combining different agents and examines the preclinical and clinical evidence supporting the effectiveness of these combinations, emphasizing their ability to enhance treatment response and overcome drug resistance. Challenges and limitations associated with combination therapy are discussed, including potential toxicity and the need for personalized treatment approaches. A future perspective is also provided to highlight the existing challenges and possible resolutions toward the clinical translation of current oral cancer therapies.

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Section: New Combinatorial Approaches For Oral Cancer Treatmentmentioning

confidence: 99%

“…COX-2 is associated with carcinogenesis and cancer cells resistance to therapy [ 44 ]. The combination showed synergistic effects, while increasing drug delivery to cancer cells [ 44 ].…”

Section: New Combinatorial Approaches For Oral Cancer Treatmentmentioning

confidence: 99%

Combination Therapy as a Promising Way to Fight Oral Cancer

et al. 2023

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“…167 Bollareddy et al prepared a transferosome hydrogel containing a 5-fluorouracil and etodolac combination for synergistic oral cancer treatment. 168 A self-healing cellulose injectable hydrogel for sustained cancer therapy was developed by Jiang et al 169 In addition, Capanema et al acquired doxorubicin-loaded bioengineered carboxymethyl cellulose hydrogels for topical chemotherapy of melanoma skin cancer. 170…”

Section: Cellulose-based Injectable Hydrogels For Targeted Chemotherapymentioning

confidence: 99%