Transfersome, an ultra-deformable lipid-based drug nanocarrier: an updated review with therapeutic applications

Simrah,; Hafeez, Abdul; Usmani, Shazia Afzal; Izhar, Mishkaat Parveen

doi:10.1007/s00210-023-02670-8

Cited by 8 publications

(2 citation statements)

References 97 publications

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“…To avoid the use of these invasive methods, transfersomes can be used for transdermal vaccine delivery; they are able to change their shape during the drug delivery and transportation throughout the skin (Fig. 4 ) [ 81 ]. The transport of transfersomes through the skin is due to the osmotic force or to the hydration.…”

Section: Nanovesicles-based Vaccinesmentioning

confidence: 99%

Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Riccardi,

Baldino,

Reverchon

2024

J Transl Med

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One of the most effective strategies to fight viruses and handle health diseases is vaccination. Recent studies and current applications are moving on antigen, DNA and RNA-based vaccines to overcome the limitations related to the conventional vaccination strategies, such as low safety, necessity of multiple injection, and side effects. However, due to the instability of pristine antigen, RNA and DNA molecules, the use of nanocarriers is required. Among the different nanocarriers proposed for vaccinal applications, three types of nanovesicles were selected and analysed in this review: liposomes, transfersomes and niosomes. PubMed, Scopus and Google Scholar databases were used for searching recent papers on the most frequently used conventional and innovative methods of production of these nanovesicles. Weaknesses and limitations of conventional methods (i.e., multiple post-processing, solvent residue, batch-mode processes) can be overcome using innovative methods, in particular, the ones assisted by supercritical carbon dioxide. SuperSomes process emerged as a promising production technique of solvent-free nanovesicles, since it can be easily scaled-up, works in continuous-mode, and does not require further post-processing steps to obtain the desired products. As a result of the literature analysis, supercritical carbon dioxide assisted methods attracted a lot of interest for nanovesicles production in the vaccinal field. However, despite their numerous advantages, supercritical processes require further studies for the production of liposomes, transfersomes and niosomes with the aim of reaching well-defined technologies suitable for industrial applications and mass production of vaccines.

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Section: Nanovesicles-based Vaccinesmentioning

confidence: 99%

Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Riccardi,

Baldino,

Reverchon

2024

J Transl Med

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“…Transfersomes have been described as specially developed vesicular particles composed of at least one inner aqueous part surrounded by a lipid layer, similar to liposomes in morphology, while, functionally, transfersomes are appropriately deformable to go across pores much smaller than their size (Simrah et al, 2024).…”

Section: Nanotechnology Solutions As a Promising Practical Approach I...mentioning

confidence: 99%

Nanophytomedicine: A promising practical approach in phytotherapy

Sardarabadi,

Darvishi,

Zohrab

et al. 2024

Phytotherapy Research

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The long and rich history of herbal therapeutic nutrients is fascinating. It is incredible to think about how ancient civilizations used plants and herbs to treat various ailments and diseases. One group of bioactive phytochemicals that has gained significant attention recently is dietary polyphenols. These compounds are commonly found in a variety of fruits, vegetables, spices, nuts, drinks, legumes, and grains. Despite their incredible therapeutic properties, one challenge with polyphenols is their poor water solubility, stability, and bioavailability. This means that they are not easily absorbed by the body when consumed in essential diets. Because of structural complexity, polyphenols with high molecular weight cannot be absorbed in the small intestine and after arriving in the colon, they are metabolized by gut microbiota. However, researchers are constantly working on finding solutions to enhance the bioavailability and absorption of these compounds. This study aims to address this issue by applying nanotechnology approaches to overcome the challenges of the therapeutic application of dietary polyphenols. This combination of nanotechnology and phytochemicals could cause a completely new field called nanophytomedicine or herbal nanomedicine.

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Polymeric micelle gel with luliconazole: in vivo efficacy against cutaneous candidiasis in Wistar rats

Singh,

Narang

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Transfersome, an ultra-deformable lipid-based drug nanocarrier: an updated review with therapeutic applications

Cited by 8 publications

References 97 publications

Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Nanophytomedicine: A promising practical approach in phytotherapy

Polymeric micelle gel with luliconazole: in vivo efficacy against cutaneous candidiasis in Wistar rats

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