Transfers in handedness in the rat resulting from small cortical lesions after limited forced practice.

Peterson, George M.; Devine, Jay

doi:10.1037/h0046933

Cited by 62 publications

(17 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1). The apparatus design was adapted from Miklyaeva and Whishaw (1996), McKenna and Whishaw (1999), Peterson and Devine, (1963) and Withers and Greenough (1989), and is described in more detail in previous studies (see Bury and Jones, 2002). Rats were trained to reach through the window to retrieve a single palatable food piece (45 mg banana-flavored pellet, Bioserve, Inc., Frenchtown, NJ) placed on a shelf (11.7 cm long × 5 cm wide × 3 cm high) in one of two shallow wells aligned 1 cm from each edge of the window.…”

Section: Reach Training Methodsmentioning

confidence: 99%

Motor cortical stimulation promotes synaptic plasticity and behavioral improvements following sensorimotor cortex lesions

Adkins

Hsu

Jones

2008

Experimental Neurology

121

133

View full text Add to dashboard Cite

Cortical stimulation (CS) as a means to modulate regional activity and excitability in cortex is emerging as a promising approach for facilitating rehabilitative interventions after brain damage, including stroke. In this study, we investigated whether CS-induced functional improvements are linked with synaptic plasticity in peri-infarct cortex and vary with the severity of impairments. Adult rats that were proficient in skilled reaching received subtotal unilateral ischemic sensorimotor cortex (SMC) lesions and implantation of chronic epidural electrodes over remaining motor cortex. Based on the initial magnitude of reaching deficits, rats were divided into severely and moderately impaired subgroups. Beginning two weeks post-surgery, rats received 100 Hz cathodal CS at 50% of movement thresholds or no-stimulation control procedures (NoCS) during 18 days of rehabilitative training on a reaching task. Stereological electron microscopy methods were used to quantify axodendritic synapse subtypes in motor cortical layer V underlying the electrode. In moderately, but not severely impaired rats, CS significantly enhanced recovery of reaching success. Sensitive movement analyses revealed that CS partially normalized reaching movements in both impairment subgroups compared to NoCS. Additionally, both CS subgroups had significantly greater density of axodendritic synapses and moderately impaired CS rats had increases in presumed efficacious synapse subtypes (perforated and multiple synapses) in stimulated cortex compared to NoCS. Synaptic density was positively correlated with postrehabilitation reaching success. In addition to providing further support that CS can promote functional recovery, these findings suggest that CS-induced functional improvements may be mediated by synaptic structural plasticity in stimulated cortex.Keywords motor rehabilitation; skilled reaching; synaptic plasticity; perforated synapses; multisynaptic boutons; stroke Motor impairments are among the most common disabilities caused by stroke (Thom et al., 2006). Motor rehabilitative training can reduce these impairments but it is often insufficient * Corresponding author. The University of Texas, 1 University Station A8000, Austin, TX 78712. Phone: +1 512 475-7763, Fax: +1 512 475-7765, dladkins@mail.utexas.edu. ‡ D.L.A and J.E.H. contributed equally to this work.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptExp Neurol. Author manuscript; available in PMC 2011 January 10. to restore normal levels of function (Duncan et al., 2000;Dobkin, 2004). Recent studies in ...

show abstract

Section: Reach Training Methodsmentioning

confidence: 99%

Motor cortical stimulation promotes synaptic plasticity and behavioral improvements following sensorimotor cortex lesions

Adkins

Hsu

Jones

2008

Experimental Neurology

121

133

View full text Add to dashboard Cite

show abstract

“…A body of work now shows that the rat can reach with a limb to retrieve food items from a shelf or tray (Peterson and Fracarol, 1938;Peterson and McGiboney, 1951;Peterson and Devine, 1963;Castro, 1972;Burke et al, 1977;Whishaw and Miklyaeva, 1996), is capable of unilateral prehension (Whishaw and Pellis, 1990;Mon-land and Jordan, 1997) analyses of reaching movements show that, when a rat uses a forelimb in skilled reaching tasks, there are proximal-to-distal gradients in the control of forelimb musculature. The movements of lifting, aiming, and advancing the paw to the food and pronating the paw over the food are produced by proximal muscles, whereas grasping the food is accomplished by movements of the distal muscles.…”

mentioning

confidence: 96%

Cervical motoneuron topography reflects the proximodistal organization of muscles and movements of the rat forelimb: A retrograde carbocyanine dye analysis

2000

View full text Add to dashboard Cite

“…This task has been modified from those described previously (Peterson and Devine, 1963;Whishaw et al, 1991). Forelimb reaching requires fine motor skill of both proximal and distal musculature as well as sensation to successfully retrieve food pellets.…”

Section: Behavioral Assessmentmentioning

confidence: 99%

Efficacy of Rehabilitative Experience Declines with Time after Focal Ischemic Brain Injury

Biernaskie¹,

Chernenko²,

Corbett³

2004

J. Neurosci.

604

463

View full text Add to dashboard Cite

To maximize the effectiveness of rehabilitative therapies after stroke, it is critical to determine when the brain is most responsive (i.e., plastic) to sensorimotor experience after injury and to focus such efforts within this period. Here, we compared the efficacy of 5 weeks of enriched rehabilitation (ER) initiated at 5 d (ER5), ER14, or ER30 after focal ischemia, as judged by functional outcome and neuromorphological change. ER5 provided marked improvement in skilled forelimb reaching ability and ladder-rung-and narrow-beam-walking tasks and attenuated the stroke-induced reliance on the unaffected forepaw for postural support. ER14 provided improvement to a somewhat lesser extent, whereas recovery was diminished after ER30 such that motor function did not differ from ischemic animals exposed to social housing.To examine potential neural substrates of the improved function, we examined dendritic morphology in the undamaged motor cortex because our previous work (Biernaskie and Corbett, 2001) suggested that recovery was associated with enhanced dendritic growth in this region. ER5 increased the number of branches and complexity of layer V neurons compared with both social housing and control animals. Dendritic arbor after ER14 (although increased) and ER30 did not differ from those exposed to social housing. These data suggest that the poststroke brain displays heightened sensitivity to rehabilitative experience early after the stroke but declines with time. These findings have important implications for rehabilitation of stroke patients, many of whom experience considerable delays before therapy is initiated.

show abstract

Transfers in handedness in the rat resulting from small cortical lesions after limited forced practice.

Cited by 62 publications

References 3 publications

Motor cortical stimulation promotes synaptic plasticity and behavioral improvements following sensorimotor cortex lesions

Motor cortical stimulation promotes synaptic plasticity and behavioral improvements following sensorimotor cortex lesions

Cervical motoneuron topography reflects the proximodistal organization of muscles and movements of the rat forelimb: A retrograde carbocyanine dye analysis

Efficacy of Rehabilitative Experience Declines with Time after Focal Ischemic Brain Injury

Contact Info

Product

Resources

About