Transferring scientific evidence to oncological practice: a trial on the impact of three different implementation strategies on antiemetic prescriptions

Roila, Fausto

doi:10.1007/s00520-003-0553-6

Cited by 36 publications

(21 citation statements)

References 2 publications

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“…3 See e.g. Grol and Grimshaw (1999); Roila (2004). 4 An interesting parallel can be drawn here with the study of factors of ICT implementation in healthcare.…”

Section: Conclusion: Interventions In Pathways and In Stsmentioning

confidence: 97%

Preventing Implementation: Exploring Interventions with Standardization in Healthcare

Zuiderent‐Jerak

2007

Science as Culture

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“…3 See e.g. Grol and Grimshaw (1999); Roila (2004). 4 An interesting parallel can be drawn here with the study of factors of ICT implementation in healthcare.…”

Section: Conclusion: Interventions In Pathways and In Stsmentioning

confidence: 97%

Preventing Implementation: Exploring Interventions with Standardization in Healthcare

Zuiderent‐Jerak

2007

Science as Culture

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“…However, education alone does not improve guideline adherence [21,22]. Studies evaluating strategies for implementing antiemetic guidelines concluded that standardized order-sets and audit-feedback improve the transferability and sustainability of guidelines into oncology practices [21,23,9]. Mertens et al found that only when adherence feedback was coupled with patient outcomes did non-adherence decrease significantly, from 73% to a sustained 0%, yielding reduced overall CINV [21].…”

Section: Background and Significancementioning

confidence: 99%

Adherence to antiemetic guidelines in patients with malignant glioma: a quality improvement project to translate evidence into practice

Affronti

Schneider

Herndon

et al. 2014

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Purpose A quality improvement project was implemented to improve adherence to evidence-based antiemetic guidelines for malignant glioma patients treated with moderately-emetic chemotherapy (MEC). Poorly controlled chemotherapy-induced nausea and vomiting (CINV) reduce cancer treatment efficacy and significantly impair cancer patients’ quality of life (QOL). Review of Duke University Preston Robert Tisch Brain Tumor Center (PRTBTC)’s usual practice demonstrates a high incidence (45%) of CINV, despite premedication with short-acting 5-HT3-serotonin receptor antagonists (5-HT3-RAs). National Comprehensive Cancer Network (NCCN)’s evidence-based guidelines recommend the combination of the long-acting 5-HT3-RA palonosetron (PAL) and dexamethasone (DEX) for the prevention of acute and delayed CINV with MEC. Low adherence (58%) to antiemetic guidelines may have explained our high CINV incidence. Methods One-sample, quasi-experimental design evaluated a combination intervention that included a provider education session; implementation of risk-assessment tool with computerized, standardized antiemetic guideline order-sets; and a monthly audit-feedback strategy. Post-implementation adherence to evidence-based antiemetic order-sets and patient outcomes were measured and compared to baseline and historical data. Primary outcome was the guideline order-set adherence rate. Secondary outcomes included nausea/vomiting rates and QOL. Results Adherence to ordering MEC guideline antiemetics increased significantly, from 58% to a sustained 90%, with associated improvement in nausea/vomiting. In acute and delayed phases, 75% and 84% of patients, respectively, did not experience CINV. There was no significant change in QOL. Conclusion Combination intervention and audit-feedback strategy to translate evidence into oncology practice improved and sustained adherence to antiemetic guidelines. Adherence corresponded with effective nausea/vomiting control and preserved QOL in patients with malignant gliomas.

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“…This creates the possibility for overtreatment by antiemetics if regimens which have evidence of efficacy for preventing emesis with anticancer drugs of moderate emetic potential are used. In an Italian Group for Antiemetic Research review of antiemetic prescribed in 4,477 patients, 509 of whom were receiving chemotherapy of low emetic potential, 65.7% were prescribed 5HT3 antagonists inappropriately [20].…”

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Guidelines for the control of nausea and vomiting with chemotherapy of low or minimal emetic potential

Olver

Clark‐Snow²,

Ballatori³

et al. 2010

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Transferring scientific evidence to oncological practice: a trial on the impact of three different implementation strategies on antiemetic prescriptions

Abstract: A combination of interventions, including an educational outreach visit, seems to be a good strategy for transferring the results of antiemetic research to oncological practice.

Cited by 36 publications

References 2 publications

Preventing Implementation: Exploring Interventions with Standardization in Healthcare

Preventing Implementation: Exploring Interventions with Standardization in Healthcare

Adherence to antiemetic guidelines in patients with malignant glioma: a quality improvement project to translate evidence into practice

Guidelines for the control of nausea and vomiting with chemotherapy of low or minimal emetic potential

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