Transferring bioelectrochemical processes from H-cells to a scalable bubble column reactor

Enzmann, Franziska; Mayer, Florian; Stöckl, Markus; Mangold, Klaus‐Michael; Hommel, R.; Holtmann, Dirk

doi:10.1016/j.ces.2018.08.056

Cited by 43 publications

(38 citation statements)

References 47 publications

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“…Another design which may be suitable for a rational scale up is an electrochemical bubble column reactor. It has been shown that this design is suitable for current generation as well as for fuel production . These studies show that modified design of typical bioreactors from biotechnology can be suitable for electrobiotechnology aiming at production of fuels and chemicals.…”

Section: Scale Up In Electrobiotechnologymentioning

confidence: 82%

“…Development of electrobioreactors based on designs known from biotechnology. (A) Stirred tank reactor for electrobiotechnology with electrodes and a second chamber within the reactor; (B) Bubble column reactor with internal electrode and surrounding counter chamber for electrobiotechnology . Further reactor designs for electrobiotechnological reactors have been described by Krieg et al (2018) …”

Section: Scale Up In Electrobiotechnologymentioning

confidence: 99%

“…This is not really a numbering up or a scale up, but rather a kind of optimization of one unit. As an example, the [40]. Further reactor designs for electrobiotechnological reactors have been described by [33] "All-in-One" electrode mentioned above could be used to place multiple electrodes into the same bioreactor [45].…”

Section: Numbering Up In Electrobiotechnologymentioning

confidence: 99%

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Same but different–Scale up and numbering up in electrobiotechnology and photobiotechnology

Enzmann

Stöckl

Zeng

et al. 2019

Engineering in Life Sciences

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Facing energy problems, there is a strong demand for new technologies dealing with the replacement of fossil fuels. The emerging fields of biotechnology, photobiotechnology and electrobiotechnology, offer solutions for the production of fuels, energy, or chemicals using renewable energy sources (light or electrical current e.g. produced by wind or solar power) or organic (waste) substrates. From an engineering point of view both technologies have analogies and some similar challenges, since both light and electron transfer are primarily surface‐dependent. In contrast to that, bioproduction processes are typically volume dependent. To allow large scale and industrially relevant applications of photobiotechnology and electrobiotechnology, this opinion first gives an overview over the current scales reached in these areas. We then try to point out the challenges and possible methods for the scale up or numbering up of the reactors used. It is shown that the field of photobiotechnology is by now much more advanced than electrobiotechnology and has achieved industrial applications in some cases. We argue that transferring knowledge from photobiotechnology to electrobiotechnology can speed up the development of the emerging field of electrobiotechnology. We believe that a combination of scale up and numbering up, as it has been shown for several photobiotechnological reactors, may well lead to industrially relevant scales in electrobiotechnological processes allowing an industrial application of the technology in near future.

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Section: Scale Up In Electrobiotechnologymentioning

confidence: 82%

Section: Scale Up In Electrobiotechnologymentioning

confidence: 99%

Section: Numbering Up In Electrobiotechnologymentioning

confidence: 99%

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Same but different–Scale up and numbering up in electrobiotechnology and photobiotechnology

Enzmann

Stöckl

Zeng

et al. 2019

Engineering in Life Sciences

Self Cite

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“…To overcome these limitations, various types of two‐chamber bioelectrochemical reactors have been developed, and empirical scale‐up strategies have been applied . However, thus far, mostly microbial electrolysis (MEC) and MFCs were scaled‐up to pilot‐ or even industrial‐scale, but to our knowledge there is only one example of the MES process using pure cultures . Enzmann et al.…”

Section: Introductionmentioning

confidence: 99%

“…Enzmann et al. developed a two‐chamber bubble column reactor (1 L working volume) derived from a MFC, which was used for the production of methane by MES using Methanococcus maripaludis . This lack of scaled‐up examples of MES using pure cultures can be attributed to the fact that most of them still have to be further optimized to secure economical scale‐up …”

Section: Introductionmentioning

confidence: 99%

Response‐Surface‐Optimized and Scaled‐Up Microbial Electrosynthesis of Chiral Alcohols

et al. 2020

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A variety of enzymes can be easily incorporated and overexpressed within Escherichia coli cells by plasmids, making it an ideal chassis for bioelectrosynthesis. It has recently been demonstrated that microbial electrosynthesis (MES) of chiral alcohols is possible by using genetically modified E. coli with plasmid‐incorporated and overexpressed enzymes and methyl viologen as mediator for electron transfer. This model system, using NADPH‐dependent alcohol dehydrogenase from Lactobacillus brevis to convert acetophenone into (R)‐1‐phenylethanol, is assessed by using a design of experiment (DoE) approach. Process optimization is achieved with a 2.4‐fold increased yield of 94±7 %, a 3.9‐fold increased reaction rate of 324±67 μm h−1, and a coulombic efficiency of up to 68±7 %, while maintaining an excellent enantioselectivity of >99 %. Subsequent scale‐up to 1 L by using electrobioreactors under batch and fed‐batch conditions increases the titer of (R)‐1‐phenylethanol to 12.8±2.0 mm and paves the way to further develop E. coli into a universal chassis for MES in a standard biotechnological process environment.

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Microbial Electrosynthesis: A Biobased Pathway for the Production of Value‐Added Chemicals Through Carbon Sequestration

Roy,

Das

2023

Microbial Electrochemical Technologies

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Transferring bioelectrochemical processes from H-cells to a scalable bubble column reactor

Cited by 43 publications

References 47 publications

Same but different–Scale up and numbering up in electrobiotechnology and photobiotechnology

Same but different–Scale up and numbering up in electrobiotechnology and photobiotechnology

Response‐Surface‐Optimized and Scaled‐Up Microbial Electrosynthesis of Chiral Alcohols

Microbial Electrosynthesis: A Biobased Pathway for the Production of Value‐Added Chemicals Through Carbon Sequestration

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