Transferring and Distributing Profiles of <i>p</i>,<i>p</i>′‐(DDT) in Egg‐forming Tissues and Eggs of Laying Hens Following a Single Oral Administration

Furusawa, Naoto

doi:10.1046/j.1439-0442.2002.00432.x

Cited by 10 publications

(3 citation statements)

References 14 publications

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“…In addition, it was also reported that DDD was detected only in the liver of laying hens after a single oral administration of p,p'-DDT (Furusawa, 2002). This finding also indicates that DDT is metabolized instantaneously to DDE and DDD in the liver.…”

Section: Discussionmentioning

confidence: 81%

A Comparative Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity of DDT in Rats Receiving a Single or Repeated Administration.

et al. 2003

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-A comparative study on the reliability of toxicokinetic parameters for predicting hepatotoxicity was conducted in male F344 rats receiving a single (106 mg/kg by gavage) or 7-day repeated (1000 ppm in feed, 97 mg/kg/day) administration of p,p'-DDT. DDT was selected as the test substance because it is known as a hepatotoxic agent and its metabolic pathway is well documented. Concentrations of DDT and its metabolites (DDE and DDD) in the plasma, brain, and liver were measured at various time intervals during the study and the results were compared with the area under the concentration-time curve (AUC) in relation to hepatotoxic response. Increases in the absolute and relative (ratio to body weight) liver weights were observed as a typical toxic response after a single or repeated exposure to DDT. The coefficient (R 2 ) of correlation between the increases in the relative liver weight and the concentrations or AUC of DDT and its metabolites in the plasma and liver was estimated. The values of R 2 between the relative liver weight and AUC of DDT or the total DDT (T-DDT) in the plasma and liver were found to be more consistent and higher than those with their concentrations in the repeated dose study. In addition, the R 2 values in correlation with their AUCs after a single exposure were lower than those in the repeated dose study. These results indicate that the AUC of DDT or T-DDT in the plasma and liver would be more reliable than their concentrations for predicting hepatotoxicity caused by DDT, especially in the repeated dose study.

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Section: Discussionmentioning

confidence: 81%

A Comparative Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity of DDT in Rats Receiving a Single or Repeated Administration.

et al. 2003

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“…(EFSA, 2006). DDT is rapidly metabolized in chickens into dichlorodiphenyldichloroethane (DDD) and dichlorodiphenyldichloroethylene (DDE), where DDD is only found in the liver and DDE is excreted in the egg (Furusawa, 2002). Most species, including humans, store DDE more efficiently than DDT (EFSA, 2006).…”

Section: Pesticidesmentioning

confidence: 99%

Chemical amd physical hazards in the egg production chain in the Netherlands

Fels‐Klerx¹,

Asselt

Pikkemaat³

et al. 2017

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Material and methods 2.1 Literature study 2.2 Monitoring data 3 The egg production chain 3.1 Chain structure in the Netherlands 3.1.1 Hatchery and rearing 3.1.2 Layer farms 3.1.3 Egg production by laying hens 3.1.4 Primary processing 3.1.5 Further processing of egg products 3.2 Production figures 3.2.1 Farms and companies 3.2.2 Egg and egg products 4 Chemical and physical hazards 4.1 Chemical hazards 4.1.1 Layer farms 4.1.2 Primary processing 4.1.3 Egg processing 4.2 Physical hazards 4.3 Most relevant chemical and physical hazards 5 Human health implications 5.1 Toxicity of dioxins 5.1.1 Acute/short-term toxicity 5.1.2 Chronic toxicity and health based guidance values 5.2 Exposure to dioxins 5.3 Burden of disease 6 Prevention and control 6.1 Entire egg production chain 6.2 Layer farms 6.3 Processing 7 Trends and forecasts 7.1 Animal husbandry systems 7.2 Feed management and import 7.3 Egg consumption 7.4 Export and import of eggs and egg products 7.4.1 Export of egg and egg products 7.4.2 Import of egg and egg products 8 Conclusion References Annex 1

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“…How well circulating contaminant levels reflect levels found in the yolk of condor eggs is currently unknown, but in laying hens, blood p,p'-DDE levels are similar to those found in the yolk and other tissues. 34 Thus, it is plausible that maternal transfer into the yolk exposes developing condor embryos to high levels of p,p'-DDE in ovo. If this is the case, the question becomes whether p,p'-DDE in ovo activate ESRs like it does in vitro and if so, is the degree of activation sufficient to alter eggshell gland development as EE 2 and o,p'-DDT do in other species?…”

Section: Mechanisms Of Eggshell Thinningmentioning

confidence: 99%

California condors and DDT: Examining the effects of endocrine disrupting chemicals in a critically endangered species

Tubbs

2016

Endocrine Disruptors

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In 1987, the last free-flying California condor (Gymnogyps californianus) was captured and brought into captivity, rendering the species extinct in the wild. At the time, only 27 condors remained. Today, the population numbers approximately 430 individuals and though condors continue their remarkable recovery, they still face numerous challenges. One challenge, specific to condors inhabiting coastal regions, is exposure to the endocrine disrupting chemical (EDC) p,p'-DDE, through the scavenging of marine mammal carcasses. The exposure levels these birds currently experience appears to be causing eggshell thinning, reminiscent of the phenomenon that nearly collapsed populations of several avian species decades ago. We were interested in further exploring the potential effects of EDCs on California condors. Investigating EDC effects on a critically endangered species like the condor can be difficult, with limited options for studies that can be feasibly conducted. Therefore, we conducted non-invasive, in vitro estrogen receptor (ESR) activation assays to characterize activation by EDCs that coastal condors encounter. Here, I give a brief history of EDCs effects on birds, and in particular the California condor. Additionally, our ESR data are summarized and mechanisms of eggshell thinning are reviewed, highlighting the potential implications of EDC exposure on the continued recovery of the California condor.

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Transferring and Distributing Profiles of p,p′‐(DDT) in Egg‐forming Tissues and Eggs of Laying Hens Following a Single Oral Administration

Cited by 10 publications

References 14 publications

A Comparative Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity of DDT in Rats Receiving a Single or Repeated Administration.

A Comparative Study on the Reliability of Toxicokinetic Parameters for Predicting Hepatotoxicity of DDT in Rats Receiving a Single or Repeated Administration.

Chemical amd physical hazards in the egg production chain in the Netherlands

California condors and DDT: Examining the effects of endocrine disrupting chemicals in a critically endangered species

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