Transferrin Subtypes in Some Eurasian and African Populations

Abstract

Transferrin (TF) subtypes in blood serum were assessed by isoelectric focusing in 2,035 healthy unrelated individuals from populations in different regions of Eurasia and Africa. Considerable heterogeneity for TF subtypes was found between the populations studied. The data obtained were compared with those of other investigators.

Chromosomal Q-Heterochromatin Polymorphism in Patients with Alimentary Obesity

“…Comparative analysis of our samples once again demonstrated our previous observations that on seven Q-polymorphic autosomes in the human genome the distribution of Q-HRs are not fortuitous. The greatest amount of Q-HRs, like in other previously examined populations, is located on autosomes 3 and 13 (more than half of all the Q-HRs), while the rest of the Q-HRs are more or less uniformly distributed on other Q-polymorphic autosomes, indicating, as we suppose, nonlocusspecificity of Q-HRs in the human genome [15][16][17][18]. Indeed, as can be seen from this Table, Q-HRs in obese individuals is encountered with an expected frequency on all the potentially Qpolymorphic autosomes [3].…”

Determination of genetic transferrin variants in human serum by high‐resolution capillary zone electrophoresis†

“…Tf‐C, the most common phenotype in all populations, encompasses 16 distinct subtypes with slightly different isoelectric points, Tf‐C1 being that with the highest prevalence (>95%) in Caucasians. Tf‐B variants with lower pI values than Tf‐C and thus more anodically migrating variants occur with lower frequencies, whereas genetic Tf‐D variants having higher pI values (more cathodically migrating variants) than Tf‐C are reported to be rare in Caucasians, but not in some other populations . Furthermore, congenital disorders of glycosylation (CDG) are a group of rare recessive inherited diseases with severe neurological and/or systemic manifestations from early childhood.…”