Transferrin receptor in proliferation of T lymphocytes in infants with iron deficiency

Artaç, Hasibe; Çoşkun, Mesut; Karadoğan, İhsan; Yegin, Olcay; Yeşilipek, Akif

doi:10.1111/j.1365-2257.2006.00848.x

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…On the other hand, since exogenous IL-2 did not fully rescue the decreased proliferation of T cells up to the values of the static control cells. CD71 as a late activation marker usually named as membrane glycoprotein transferrin receptor (TfR) that is up-regulated as a mechanism to meet the increased iron demands associated with increased metabolism of activated T cells, and meanwhile to act as a housekeeping receptor that binds iron-loaded transferrin at cell surface and trigger internalization 36,37. Moreover, the newest study demonstrated that CD71 was identified as a novel IKK-binding partner and involved in IKK-NF-κB signaling pathway that exerted transcriptional control over a large number of genes significantly induced during T cell activation 38,39.…”

Section: Discussionmentioning

confidence: 99%

Microgravity Inhibits Resting T Cell Immunity in an Exposure Time-Dependent Manner

et al. 2014

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Background: Decline immune function is well documented after spaceflights. Microgravity is one of the key factors directly suppressing the function of immune system. Though T cell immune response was inhibited by microgravity, it is not clearly whether activation would be inhibited after a pre-exposure of microgravity on T lymphocytes at the resting state. Methods: We herein investigated the response ability of resting CD4+ and CD8+ T cells experiencing pre-exposure of modeled microgravity (MMg) for 0, 8, 16 and 24 hrs to concanavalin A (ConA) stimulation. The phenotypes and subsets of immune cells were determined by flow cytometry. Results: Both CD4+ and CD8+ T cells with an MMg pre-exposure exhibited decreased expressions of activation-markers including CD25, CD69 and CD71, inflammatory cytokine secretion and cell proliferation in response to ConA compared with T cells with 1g controls in an MMg exposure time- dependent manner. Moreover, short term MMg treatment caused more severe decreased proliferation in CD4+ T cells than in CD8+ T cells. Conclusions: MMg can directly impact on resting T cell subsets. CD4+ T cells were more sensitive to the microgravity inhibition than CD8+ T cells in respect of cell proliferation. These results offered new insights for the MMg-caused T cell functional defects.

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Section: Discussionmentioning

confidence: 99%

Microgravity Inhibits Resting T Cell Immunity in an Exposure Time-Dependent Manner

et al. 2014

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“…37 Biomarkers that fit currently accepted biological and physiologic paradigms are more readily accepted by the research and clinical communities. 41 TFR2 is also important in regulating iron homeostasis and, interestingly, dysregulated iron homeostasis has been observed in lung allograft patients. 37 Given the profound disturbance that allograft rejection-related processes can have at a cellular and molecular level, it is not surprising that we observed 1,295 probe-sets whose expression levels differ in AR vs NR patients.…”

Section: Integration Of Biological Information and Interpretationmentioning

confidence: 99%

“…Further, patients 39 disruption in iron homeostasis observed in lung allograft patients 40 • TFR2 levels upregulated in activated T cells 41 ; T-cell activation is an expected phenomenon during allograft rejection KLF4 Larger training and testing cohorts would be desirable.…”

Section: Potential Application Of the Biomarker Panel And Caveats Formentioning

confidence: 99%

Whole Blood Genomic Biomarkers of Acute Cardiac Allograft Rejection

Lin¹,

Hollander²,

Ng³

et al. 2009

The Journal of Heart and Lung Transplantation

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“…Moreover, it remains unknown about the relationship between CD69 spatial and temporal distribution and CD69 immunoregulatory function. Upon activation, CD71 on T cells is up-regulated as a mechanism to meet the increased iron demands associated with increased metabolism, and meanwhile to act as a housekeeping receptor that binds iron-loaded transferrin at cell surface and trigger internalization[13,14]. However, little is known about how CD71 binds iron-loaded transferrin and mediates endocytosis on cell membrane.…”

Section: Introductionmentioning

confidence: 99%

NSOM/QD-based fluorescence–topographic image fusion directly reveals nano-spatial peak–valley polarities of CD69 and CD71 activation molecules on cell-membrane fluctuations during T-cell activation

Zhong

Zhang

et al. 2011

Immunology Letters

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Nano-spatial distribution of cell surface molecules on cell membrane fluctuations during T-cell activation has not been reported. In this study, we innovated application of near-field scanning optical microscopy (NSOM)/quantum dots (QD)-based nanotechnology through three-dimensional image fusion algorithm to merge the simultaneously-obtained dual-color fluorescence information and three-dimensional topography. This novel imaging system made it possible to visualize nano-spatial distribution and organization of early-activation molecules CD69 and late-activation molecules CD71 on cell-membrane fluctuations during T-cell activation. Interestingly, most CD69 molecules were clustered to form 250–500 nm nano-domains polarizing predominantly in the peak of the cell-membrane fluctuations. In contrast, although CD71 molecules were also clustered as 250–500 nm nano-domains, they polarized dominantly in the valley of the cell-membrane fluctuations. The peak-valley polarities of CD69 nano-domains and CD71 nano-domains implied their different functions. CD69 nano-domains polarizing on membrane-peak fluctuations might serve as transient platforms driving TCR/CD3-induced signaling and activation, whereas CD71 nano-domains distributing in the membrane-valley fluctuations appeared to facilitate iron uptake for increased metabolisms in T-cell activation. Importantly, this NSOM/QD-based fluorescence-topographic image fusion provides a powerful tool to visualize nano-spatial distribution of cell-surface molecules on cell-membrane fluctuations and enable better understanding of distribution-function relationship.

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Transferrin receptor in proliferation of T lymphocytes in infants with iron deficiency

Cited by 7 publications

References 21 publications

Microgravity Inhibits Resting T Cell Immunity in an Exposure Time-Dependent Manner

Microgravity Inhibits Resting T Cell Immunity in an Exposure Time-Dependent Manner

Whole Blood Genomic Biomarkers of Acute Cardiac Allograft Rejection

NSOM/QD-based fluorescence–topographic image fusion directly reveals nano-spatial peak–valley polarities of CD69 and CD71 activation molecules on cell-membrane fluctuations during T-cell activation

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