“…11 We present here the first evidence that the same activation is operating in hepatocytes and that ERK activation is necessary for holotransferrin-induced hepcidin gene expression. Interestingly, we also showed that holotransferrin regulates hepcidin mRNA concentrations through a HJV/BMP dependent pathway since the effect of holotransferrin was lost in the presence of noggin and BMP2/4 antibodies.…”