Transferrin-inspired vehicles based on pH-responsive coordination bond to combat multidrug-resistant breast cancer

He, Yujing; Liu, Xing; Cui, Pengfei; Zhang, Jialiang; Zhu, Yong; Qiao, Jian-Bin; Lyu, Jin-Yuan; Zhang, Mei; Luo, Cheng-Qiong; Zhou, Yuxin; Lu, Na; Jiang, Hu‐Lin

doi:10.1016/j.biomaterials.2016.11.001

Cited by 63 publications

(35 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, the auger chemical shift (3.5 eV) compared with the binding energy of Fe(NO 3 ) 3 suggested that Fe 3+ was coordinated with DOX. And this result was consistence with the previous report . Moreover, the UV–vis spectrum verified that the absorption band of DOX slightly shifted to the red, and typical absorbance shoulder peaks between 600 and 700 nm appeared for FGC@DOX (Figure D), which further substantially demonstrated the coordination interaction between Fe 3+ and DOX .…”

Section: Resultssupporting

confidence: 90%

pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

Han

Zhang

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

Both excess dosages of drug and unwanted drug carrier can lead to severe side effects as well as the failure of tumor therapy. Here, an Fe -gallic acid based drug delivery system is designed for efficient monitoring of drug release in tumor. Fe and polyphenol gallic acid can form polygonal nanoscale coordination polymer in aqueous solution, which exhibits certain antitumor effect. Importantly, this coordination polymer possesses extremely high doxorubicin (DOX) loading efficacy (up to 48.3%). In vitro studies demonstrate that the fluorescence of DOX can be quenched efficiently when DOX is loaded on the coordination polymer. The acidity in lysosome also triggers the release of DOX and fluorescence recovery simultaneously, which realizes real-time monitoring of drug release in tumor cells. In vivo studies further indicate that this polyphenol-rich drug delivery system can significantly inhibit tumor growth with negligible heart toxicity of DOX. This system with minimal side effects should be a promising nanoplatform for tumor treatment.

show abstract

Section: Resultssupporting

confidence: 90%

pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

Han

Zhang

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Drug delivery systems via nanoparticles (NPs) can improve the pharmacologic properties of traditional chemotherapy drugs and ameliorate the therapeutic index [2][3][4][5]. Consequently, a biomimetic drug delivery system (Tf-inspired-NPs), inspired by the pH-dependent ferric ion transport and release manner of transferrin, was previously developed for combating doxorubicin-resistant breast cancer [6]. But, the delivery system is not an active targeted process, the Tf-inspired-NPs must first accumulate passively in tumor due to the enhanced permeation and retention effect (EPR), followed by binding to tumor cells.…”

Section: Introductionmentioning

confidence: 99%

“…We uploaded a doxorubicin-transferrin-inspired drug delivery system (Tf-inpsired-NPs) to human umbilical cord mesenchymal stem cells (hUC-MSCs) for tumor-tropic therapy. Tf-inspired-NPs were prepared via environment-friendly method and were well redisposed in saline solution after lyophilization [6]. Tf-inspired-NPs loaded hUC-MSCs showed no significant adverse effect on cell proliferation, viability and tropic ability towards MCF-7 human breast cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of doxorubicin for breast cancer therapy

Cao

Guo

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

The main challenge of anticancer drugs is poor tumor targeting. Now cellular carriers are widely investigated to deliver anticancer agents. As an ideal cellular candidate, human umbilical cord derived mesenchymal stem cells (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed hUC-MSCs carrying transferrin-inspired-nanoparticles that contain doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and made an evaluation. Results represented that hUC-MSCs-Tf-inspired-NPs not only exhibit the controlled-release property of Tf-inspired-NPs, but also integrate tumor tropism and penetrative abilities of MSCs. The tumor volume of nude mice bearing breast cancer MCF-7 treated with hUC-MSCs-Tf-inspired-NPs, was remarkably reduced compared to those treated with free drug or Tf-inspired-NPs. Thus, Tf-inspired-NPs loaded hUC-MSCs have a potential to deliver anticancer drugs.

show abstract

“…Transferrin is involved in cellular iron transportation by receptor-mediated endocytosis. Recently, transferrin has been used as an efficient carrier of therapeutic molecules to overcome drug resistance in many cancers such as breast cancer, lung cancer or glioblastoma [32][33][34]. BIM acts as an apoptotic activator and its expression is associated with good prognosis in colon cancer [35].…”

mentioning

confidence: 99%

Dishevelled segment polarity protein 3 (DVL3): a novel and easily applicable recurrence predictor in localised prostate adenocarcinoma

Kim

Park²,

Kim

et al. 2017

BJU International

View full text Add to dashboard Cite

show abstract

Transferrin-inspired vehicles based on pH-responsive coordination bond to combat multidrug-resistant breast cancer

Cited by 63 publications

References 55 publications

pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of doxorubicin for breast cancer therapy

Dishevelled segment polarity protein 3 (DVL3): a novel and easily applicable recurrence predictor in localised prostate adenocarcinoma

Contact Info

Product

Resources

About