Transferrin bei Fr�hgeborenen

Weippl, G

doi:10.1007/bf00440512

Cited by 4 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Böhles (1997) recently suggested a critical reevaluation of the metabolic effects of vitamin C, because high concentrations of the vitamin in the presence of free iron have pro-oxidant capabilities, supporting free radical formation (Fenton's reagent) (Frei et al, 1989). Several reports indicate that free iron may be more available in preterm than in term infants (Berger et al, 1990;Evans et al, 1992;Shaw, 1982;Sullivan, 1988;von Weippl, 1962). Vita-min C at concentrations observed in preterm infants inhibited the ferroxidase activity of ceruloplasmin, assessed by in vitro tests (Powers H.J.…”

Section: Review Of the Literaturementioning

confidence: 99%

Nutrient Requirements For Preterm Infant Formulas

Klein

2002

The Journal of Nutrition

327

231

View full text Add to dashboard Cite

Achieving appropriate growth and nutrient accretion of preterm and low birth weight (LBW) infants is often difficult during hospitalization because of metabolic and gastrointestinal immaturity and other complicating medical conditions. Advances in the care of preterm-LBW infants, including improved nutrition, have reduced mortality rates for these infants from 9.6 to 6.2% from 1983 to 1997. The Food and Drug Administration (FDA) has responsibility for ensuring the safety and nutritional quality of infant formulas based on current scientific knowledge. Consequently, under FDA contract, an ad hoc Expert Panel was convened by the Life Sciences Research Office of the American Society for Nutritional Sciences to make recommendations for the nutrient content of formulas for preterm-LBW infants based on current scientific knowledge and expert opinion. Recommendations were developed from different criteria than that used for recommendations for term infant formula. To ensure nutrient adequacy, the Panel considered intrauterine accretion rate, organ development, factorial estimates of requirements, nutrient interactions and supplemental feeding studies. Consideration was also given to long-term developmental outcome. Some recommendations were based on current use in domestic preterm formula. Included were recommendations for nutrients not required in formula for term infants such as lactose and arginine. Recommendations, examples, and sample calculations were based on a 1000 g preterm infant consuming 120 kcal/kg and 150 mL/d of an 810 kcal/L formula. A summary of recommendations for energy and 45 nutrient components of enteral formulas for preterm-LBW infants are presented. Recommendations for five nutrient:nutrient ratios are also presented. In addition, critical areas for future research on the nutritional requirements specific for preterm-LBW infants are identified.

show abstract

Section: Review Of the Literaturementioning

confidence: 99%

Nutrient Requirements For Preterm Infant Formulas

Klein

2002

The Journal of Nutrition

327

231

View full text Add to dashboard Cite

show abstract

“…Although these conclusions about human iron metabolism are well-established for adults, iron biochemistry in neonates may be different [8,9]. There are several reports that neonates, particularly pro-term, have compromised antioxidant defences, such as low activities of antioxidant enzymes [10] and low concentrations of to- copherols [11].…”

Section: Introductionmentioning

confidence: 99%

“…bronchopulmonary dysplasia) in pre-term neonates [10,12] and may correlate with the chances of poor outcome [13]. Several reports also suggest that 'free' iron may be more available in pre-term neonates [8,934]. For example, in a study of rhesus haemolytic disease, Berger et al [15] found that cord blood of babies with this disease had lower levels of iron-binding capacity and plasma ascorbic acid.…”

Section: Introductionmentioning

confidence: 99%

Bleomycin‐detectable iron in the plasma of premature and full‐term neonates

Evans

Kovar

et al. 1992

FEBS Letters

View full text Add to dashboard Cite

The bleomycin assay measures non‐transferrin‐bound iron, able to catalyze free radical reactions, in human plasma. No bleomycin‐detectable iron is present in plasma from healthy adults. However, plasma from 3/15 premature babies was positive in this assay. Plasma from 52 apparently‐healthy term babies was analyzed and 11 were positive in the bleomycin assay. Hence not only some premature but also some full‐term apparently‐healthy babies may be at risk of severe oxidative damage.

show abstract