Transferências lipídicas para HDL em diabéticos tipo 2: associações com microalbuminúria, estatina e insulina

Feitosa-Filho, Gilson Soares; Seydell, Talita de Mattos; Feitosa, Alina Coutinho Rodrigues; Maranhão, Raul C.; Ramires, José Antônio Franchini

doi:10.1590/s0066-782x2009000200005

Cited by 5 publications

(3 citation statements)

References 44 publications

(39 reference statements)

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“…A study in people with dyslipidaemia however showed a reduction in COH levels after treatment with simvastatin, as compared to placebo 36 . Another study also reported lower COH levels in patients with T2DM on statins than in those who were not 37 . Whilst these studies demonstrate the efficacy of statins in reducing COH levels in individuals with pre-existing altered lipid metabolism, supplementation with carnosine preserved COH levels in obese and overweight people with normal lipid profiles.…”

Section: Discussionmentioning

confidence: 87%

Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial

Baye

Ukropec

Courten

et al. 2017

Sci Rep

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Carnosine has been shown to reduce oxidation and glycation of low density lipoprotein hence improving dyslipidaemia in rodents. The effect of carnosine on human plasma lipidome has thus far not been investigated. We aimed to determine whether carnosine supplementation improves the plasma lipidome in overweight and obese individuals. Lipid analysis was performed by liquid chromatography mass spectrometry in 24 overweight and obese adults: 13 were randomly assigned to 2 g carnosine daily and 11 to placebo, and treated for 12 weeks. Carnosine supplementation maintained trihexosylceramide (0.01 ± 0.19 vs −0.28 ± 0.34 nmol/ml, p = 0.04), phosphatidylcholine (77 ± 167 vs −81 ± 196 nmol/ml, p = 0.01) and free cholesterol (20 ± 80 vs −69 ± 80 nmol/ml, p = 0.006) levels compared to placebo. Trihexosylceramide was inversely related with fasting insulin (r = −0.6, p = 0.002), insulin resistance (r = −0.6, p = 0.003), insulin secretion (r = −0.4, p = 0.05) and serum carnosinase 1 activity (r = −0.3, p = 0.05). Both phosphatidylcholine and free cholesterol did not correlate with any cardiometabolic parameters. Our data suggest that carnosine may have beneficial effects on the plasma lipidome. Future larger clinical trials are needed to confirm this.

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Section: Discussionmentioning

confidence: 87%

Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial

Baye

Ukropec

Courten

et al. 2017

Sci Rep

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“…In a previous study, we compared lipid transfers to HDL measured in T2DM without microalbuminuria with those with microalbuminuria, that is a more advanced disease stage and no difference was found between the two groups. This may suggest that aggravation of diabetes complications does not interfere with the lipid transfers [43]. …”

Section: Discussionmentioning

confidence: 99%

Removal from the plasma of the free and esterified forms of cholesterol and transfer of lipids to HDL in type 2 diabetes mellitus patients

et al. 2012

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BackgroundThe aim was to investigate new markers for type 2 diabetes (T2DM) dyslipidemia related with LDL and HDL metabolism. Removal from plasma of free and esterified cholesterol transported in LDL and the transfer of lipids to HDL are important aspects of the lipoprotein intravascular metabolism. The plasma kinetics (fractional clearance rate, FCR) and transfers of lipids to HDL were explored in T2DM patients and controls, using as tool a nanoemulsion that mimics LDL lipid structure (LDE).Results14C- cholesteryl ester FCR of the nanoemulsion was greater in T2DM than in controls (0.07 ± 0.02 vs. 0.05 ± 0.01 h-1, p = 0.02) indicating that LDE was removed faster, but FCR 3 H- cholesterol was equal in both groups. Esterification rates of LDE free-cholesterol were equal. Cholesteryl ester and triglyceride transfer from LDE to HDL was greater in T2DM (4.2 ± 0.8 vs. 3.5 ± 0.7%, p = 0.03 and 6.8 ± 1.6% vs. 5.0 ± 1.1, p = 0.03, respectively). Phospholipid and free cholesterol transfers were not different.ConclusionsThe kinetics of free and esterified cholesterol tended to be independent in T2DM patients and the lipid transfers to HDL were also disturbed. These novel findings may be related with pathophysiological mechanisms of diabetic macrovascular disease.

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“…Isso pode ser explicado devido a presença de morbidades crônicas influenciarem o desenvolvimento de outras morbidades, principalmente com as modificações fisiológicas do envelhecimento (Ministério da Saúde, 2013). Ademais, estudo identificou que em indivíduos diabéticos, o HDL possui maior capacidade para captar fosfolípides e colesterol livre(Feitosa-Filho et al, 2009).Apesar da variável sexo não ter sido associada a dislipidemia do HDL-c na presente investigação, outros estudos(González-Rivas et al, 2018;Alessa et al, 2015; Frank et al, 2014) sinalizam a importância epidemiológica dessa associação, desfavorável ao sexo feminino, que pode ser explicada pelo impacto das variações hormonais estrogênicas, que potencializam o adoecimento dislipidêmico e aterosclerótico(O'Brien, Nguyen, 1997).…”

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Fatores associados a dislipidemia do colesterol da lipoproteína de alta densidade em quilombolas

Santos

Almeida

Santos

et al. 2020

RSD

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O presente estudo teve o objetivo de analisar a prevalência da dislipidemia do colesterol da lipoproteína de alta densidade (HDL-c) e fatores associados em população quilombola baiana. Trata-se de um estudo de base populacional, com 850 adultos de ambos os sexos. A dislipidemia do HDL-c foi determinada para valores <50 mg/dl para mulheres e <40 mg/dl para homens, conforme a atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose. A regressão de Poisson, bruta e ajustada, foi usada para testar as associações. A prevalência da dislipidemia do HDL-c foi de 17,5% (Intervalo de Confiança 95%: 14,9:20,0). Os fatores associados (p<0,05) a dislipidemia foram: a idade, situação conjugal, hipertensão e diabetes. Conclui-se que a dislipidemia do HDL-c é mais prevalente em quilombolas mais velhos, casados, hipertensos e diabéticos.

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Transferências lipídicas para HDL em diabéticos tipo 2: associações com microalbuminúria, estatina e insulina

Abstract: SummaryBackground: Type-2 diabetes mellitus (T2DM) is an isolated risk factor for coronary artery disease, especially when associated with microalbuminuria (MA). Structural and functional changes in lipoproteins have not yet been fully elucidated in this context.

Cited by 5 publications

References 44 publications

Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial

Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial

Removal from the plasma of the free and esterified forms of cholesterol and transfer of lipids to HDL in type 2 diabetes mellitus patients

Fatores associados a dislipidemia do colesterol da lipoproteína de alta densidade em quilombolas

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