Transfer pathways between the ovaries and the uterus in the cebus monkeys (Cebus apella)

Nagle, Carlos A.; Mendizabal, A. F.; Lahoz, Mónica; Porta, Micaela; Torres, M.

doi:10.1016/j.ygcen.2005.06.006

Cited by 2 publications

(2 citation statements)

References 42 publications

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“…The endometrial release of PGF2 in response to oxytocin is the initial signal triggering luteolysis in animals, and ovarian PGF2 contributes to the luteolytic process in primates including humans [68]. In presence of a viable embryo, the default luteolytic signal is counteracted by an antiluteolytic or a luteotrophic signal or a combination of both to maintain the production of progesterone.…”

Section: Prostaglandin F2 (Akr1c3 and Akr1b5)mentioning

confidence: 99%

Role of Candidate Genes Regulating Uterine Prostaglandins Biosynthesis for Maternal Recognition of Pregnancy in Domestic Animals

et al. 2013

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The survivability and opportunity of successful development of an embryo are influenced directly or indirectly by factors controlling uterine microenvironment. Out of all factors, hormones such as prostaglandins (PGs) released during the preimplantation period influence molecular interactions involved in maintenance of pregnancy through reciprocal interactions between the conceptus and endometrium. PGs are important regulators of female reproductive functions, namely, ovulation, uterine receptivity, implantation, and parturition. Among different classes of PGs, prostaglandin F2 (PGF2 ) and prostaglandin E2 (PGE2) are main prostanoids produced by human and bovine endometrium for successful growth and development of the posthatching blastocyst. In ruminants, PGF2 produced by endometrium is the major luteolytic agent, whereas PGE2 has luteoprotective and antiluteolytic properties. Therefore, the development and maintenance of the corpus luteum (CL), as well as establishment of pregnancy, depend on the balance of luteolytic PGF2 and luteotropic PGE2. In this review, we discussed the expression and function of genes which predominantly regulate the synthesis and their secretion of PGF2 and PGES, namely, PGFS (AKR1B5/AKR1C3), PGES, PGFR, and COX-2.

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Section: Prostaglandin F2 (Akr1c3 and Akr1b5)mentioning

confidence: 99%

Role of Candidate Genes Regulating Uterine Prostaglandins Biosynthesis for Maternal Recognition of Pregnancy in Domestic Animals

et al. 2013

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“…In these species, it triggers the luteal production of PGF 2α (Tsai & Wiltbank 1997, Arosh et al 2004, probably crucial for complete structural regression (Diaz et al 2002, Hayashi et al 2003. In primates, luteal regression is mediated by PGF 2α of luteal rather than uterine origin (Nagle et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and reception of prostaglandins in corpora lutea of domestic cat and lynx

Zschockelt¹,

Amelkina²,

Siemieniuch³

et al. 2016

Reproduction

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Felids show different reproductive strategies related to the luteal phase. Domestic cats exhibit a seasonal polyoestrus and ovulation is followed by formation of corpora lutea (CL). Pregnant and non-pregnant cycles are reflected by diverging plasma progesterone (P4) profiles. Eurasian and Iberian lynxes show a seasonal monooestrus, in which physiologically persistent CL (perCL) support constantly elevated plasma P4 levels. Prostaglandins (PGs) represent key regulators of reproduction, and we aimed to characterise PG synthesis in feline CL to identify their contribution to the luteal lifespan. We assessed mRNA and protein expression of PG synthases (PTGS2/ COX2, PTGES, PGFS/AKR1C3) and PG receptors (PTGER2, PTGER4, PTGFR), and intra-luteal levels of PGE 2 and PGF 2α . Therefore, CL of pregnant (pre-implantation, post-implantation, regression stages) and non-pregnant (formation, development/maintenance, early regression, late regression stages) domestic cats, and prooestrous Eurasian (perCL, pre-mating) and metoestrous Iberian (perCL, freshCL, post-mating) lynxes were investigated. Expression of PTGS2/COX2, PTGES and PTGER4 was independent of the luteal stage in the investigated species. High levels of luteotrophic PGE 2 in perCL might be associated with persistence of luteal function in lynxes. Signals for PGFS/AKR1C3 expression were weak in mid and late luteal stages of cats but were absent in lynxes, concomitant with low PGF 2α levels in these species. Thus, regulation of CL regression by luteal PGF 2α seems negligible. In contrast, expression of PTGFR was evident in nearly all investigated CL of cat and lynxes, implying that luteal regression, e.g. at the end of pregnancy, is triggered by extra-luteal PGF 2α .

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Transfer pathways between the ovaries and the uterus in the cebus monkeys (Cebus apella)

Cited by 2 publications

References 42 publications

Role of Candidate Genes Regulating Uterine Prostaglandins Biosynthesis for Maternal Recognition of Pregnancy in Domestic Animals

Role of Candidate Genes Regulating Uterine Prostaglandins Biosynthesis for Maternal Recognition of Pregnancy in Domestic Animals

Synthesis and reception of prostaglandins in corpora lutea of domestic cat and lynx

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