Transfer of Radioiodinated Human Serum Albumin (RISA(R)) from Cerebrospinal Fluid to Blood Plasma.

CSF imaging in benign intracranial hypertension

“…In the normal dogs the mean percentage of injected radioactivity found in the circulatory plasma at 24 hours was 46% whereas in the hydrocephalic animals only 16% was present. These findings correspond to those published by Van Wart et al (1960) and in animals with communicating hydrocephalus by Strecker et al (1973). In seven normal patients and six patients with communicating hydrocephalus the values were 48 and 24%.…”

Kinetics of movement of iodide, sucrose, inulin and radio‐iodinated serum albumin in the central nervous system and cerebrospinal fluid of the rat

“…Since iodide (Wallace & Brodie, 1937, 1939, 1940aGildea & Man, 1943;Greenberg, Aird, Boelter, Campbell, Cohn & Muryama, 1943;Davson, 1955;Davson & Spaziana, 1959), sucrose (Hubbard & Zoll, 1949;Deane, Schreiner & Robertson, 1951;Gamble, Robertson, Hannigan, Foster & Farr, 1953;Davson & Matchett, 1953;Davson, 1955;Peterson, O'Toole, Kirkindall & Kemp-Thorne, 1959), inulin (McLennan, 1957;Morrison, 1959: Rothman, Freireich, Gaskins, Patlak & Rail, 1961, and serum albumin (Fishman, 1953;Rozdilsky & Olszewski, 1957;Van Wart, Dupont & Kraintz, 1960;Lee & Olszewski, 1960;Brown, 1961) have been used in various space measurements and barrier studies, and since they are relatively non-toxic substances, representinlg both charged and uncharged molecules and ions that have markedly different molecular weights (iodide 127, sucrose 342, inulin 3000-4000, albumin 69,000), they were selected for the present studies of transport and barrier mechanisms. In this investigation the tracers were administered to rats intraperitoneally (i.P.…”

Decreased cerebrospinal fluid absorption during abdominal insufflation

“…1.). This variability was probably due to the unreliability of serum RISA levels normally seen in the first 2 h of uptake [14]. Therefore, the percent change of RISA levels was calculated for each animal between set time periods.…”