Transfer of Psychiatric Inpatients to a General Hospital Due to Adverse Drug Reactions

Adverse Drug Reactions in Hospitalized Psychiatric Patients

“…Our analysis showed that psychiatric medications were responsible for 63.2% of the pADRs, which is similar to the 68% reported by Rothschild et al In our data, however, lithium was responsible for the most frequent number of pADRs, while second-generation antipsychotics accounted for the largest portion in the study by Rothschild et al Other medication safety studies in psychiatric patients have not focused on pADRs. 14…”

Identification and management of adverse effects of antipsychotics in a tertiary care teaching hospital

“…[2] adverse drug reactions (ADRs) were responsible for 0.3% of transfers from a psychiatric hospital to a medical facility and the cause of 10/1000 patient days in psychiatric hospitals. [34] According to various studies, most of the ADRs in the psychiatry department is reported with antidepressants and antipsychotics. [567] The second-generation antipsychotics, especially clozapine and olanzapine, generally tend to cause more problems relating to metabolic disorders but the older first-generation antipsychotics are more likely to be associated with movement disorders.…”

Adverse Drug Reactions: A Retrospective Review of Hospitalized Patients at a State Psychiatric Hospital

“…Although information regarding ADRs in medical hospital inpatients abounds, knowledge about the tolerability of psychotropic agents in psychiatric inpatients is sparse. [1][2][3][4][5][6][7] ADRs have not been studied as extensively in hospitalized psychiatric patients, as these patients may present challenges not seen in the nonpsychiatric patient population. For example, it may be difficult to distinguish antipsychotic-induced akathisia from underlying anxiety.…”

“…They found that transfers were not frequent, but 76% of the transfers involved neurological reactions, including delirium, seizures, and syncope, and 32% of transfers involved the use of more than 1 psychotropic drug. 4 A health care system can use data on frequency, severity, probability, and preventability to identify medications that should be targeted for quality improvement projects and patient education. Targeting high-risk medications that have been identified through analysis could have a significant impact on reducing preventable ADRs.…”

“…Rothschild et al 3 found that preventable ADRs (pADRs) accounted for 13% of all ADRs in a psychiatric hospital and that atypical antipsychotics accounted for 37% of all ADRs. Popli et al 4 studied the transfer of psychiatric patients to a medical hospital due to ADRs. They found that transfers were not frequent, but 76% of the transfers involved neurological reactions, including delirium, seizures, and syncope, and 32% of transfers involved the use of more than 1 psychotropic drug.…”