Transfer of plasmid Hly in vivo in pigs intestine

Klimuszko, D.; Szynkiewicz, Z.; Piekarowicz, Andrzej; Binek, M.; Wójcik, Urszula

doi:10.1016/0147-9571(89)90006-4

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Many of the factors involved in the host–microbe interactions of gut-mediated HGT are not yet understood ( Stecher et al, 2012 ; Ott et al, 2020 ). Limited in vivo studies have been conducted to determine the roles of factors such as host immunity, antibiotic treatment status, gut environmental conditions, and secretory molecules in the interactions of microbial HGT ( Klimuszko et al, 1989 ; Thomas and Nielsen, 2005 ; Diaz et al, 2012 ; Stecher et al, 2012 ; Huddleston, 2014 ; Machado and Sommer, 2014 ; Getino et al, 2015 ; Zeng and Lin, 2017 ; Devanga Ragupathi et al, 2019 ; Ott et al, 2020 ). While there have been many publications reporting the transfer of AR plasmids in vitro , often in the context of soil or wastewater, there has been a stark lack of experiments that demonstrate the interactions of these bacteria in vivo ( Macuch et al, 1967 ; Rang et al, 1996 ; Gevers et al, 2003 ; Card et al, 2017 ; Benz et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Models for Gut-Mediated Horizontal Gene Transfer by Bacterial Plasmid Conjugation

Ott

Mellata

2022

Front. Microbiol.

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Graphical Abstract Models for gut-mediated bacterial conjugation and plasmid transfer. Depiction of conjugative elements (Left, Top), current in silico models (Left, Middle), experimental in vitro models (Left, Bottom), and in vivo animal models (Right) for bacterial conjugation in the gut. Arthropods; spring tails (Folsomia candida), fleas (Alphitobius diaperinus), fruit flies (Drosophila melanogaster), house flies (Musca domestica), beetles (Xenopsylla cheopis); Rhabditidae; nematodes (Caenorhabditis elegans); Phasianidae; chickens (Gallus gallus). Leporidae; rabbits (Oryctolagus cuniculus). Muridae; mice (Mus musculus), rats (Mus rattus).

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Section: Introductionmentioning

confidence: 99%

Models for Gut-Mediated Horizontal Gene Transfer by Bacterial Plasmid Conjugation

Ott

Mellata

2022

Front. Microbiol.

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“…Live-animal (in vivo) experiments successfully target the bacterial environment and cannot be replaced, but they prove costly to run, difficult to initiate, and hard to control absolutely (11). The usual species used in these investigations are laboratory mice; however, a few studies have investigated bacterial transfer in other host species, such as rats (6), chickens (8), pigs (31,67), and dogs (46). Rodents typically harbor a flora very different from that of humans and farm animals, especially ruminants (18).…”

Section: Vol 74 2008 Resistance Gene Transfer Rates During Conjugatmentioning

confidence: 99%

Meta-Analysis of Experimental Data Concerning Antimicrobial Resistance Gene Transfer Rates during Conjugation

Hunter

Wilkinson

Catling

et al. 2008

Appl Environ Microbiol

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This paper presents the results of a meta-analysis of published transfer rates of antimicrobial resistance genes. A total of 34 papers were identified, of which 28 contained rates estimated in relation to either donor or recipient bacterial counts. The published rates ranged from 10 ؊2 to 10 ؊9. Generalized linear modeling was conducted to identify the factors influencing this variation. Highly significant associations between transfer frequency and both the donor (P ‫؍‬ 1.2 ؋ 10 ؊4 ) and recipient (P ‫؍‬ 1.0 ؋ 10 ؊5 ) genera were found. Also significant was whether the donor and recipient strains were of the same genus (P ‫؍‬ 0.023) and the nature of the genetic element (P ‫؍‬ 0.0019). The type of experiment, in vivo or in vitro, approached statistical significance (P ‫؍‬ 0.12). Parameter estimates from a general linear model were used to estimate the probability of transfer of antimicrobial resistance genes to potential pathogens in the intestine following oral ingestion. The mean logarithms of these probabilities are in the range of [؊7.0, ؊3.1]. These probability distributions are suitable for use in the quantitative assessment of the risk of transfer of antimicrobial resistance genes to the intestinal flora of humans and animals.

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Antimicrobial Resistance: Implications for the Food System

Doyle¹,

Busta

Cords

et al. 2006

Comp Rev Food Sci Food Safe

109

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The safety of food worldwide remains challenged by the potential for emergence of new pathogens and re‐emergence of known pathogens. Microorganisms have an inherent ability to evolve—to mutate and adapt to environmental stressors—allowing them to survive otherwise lethal conditions. The Institute of Food Technologists (IFT),1 the 22000‐member nonprofit scientific and educational society, convened a panel of internationally renowned experts to address the concern that the use of antimicrobials in food production, manufacturing, and elsewhere may lead to the emergence of foodborne pathogens that are resistant to antimicrobials, thus compromising the ability to subsequently control them, whether in production agriculture, food processing, or human medicine. The outcome of the panel's deliberations is presented in this Expert Report. IFT's objective for this Expert Report is to increase the understanding—among IFT members, senior policy officials, and other interested groups—of the state of the science on the public health impact of the use of antimicrobials in the food system, and development and control of antimicrobial resistance. This report is the fourth Expert Report produced by IFT.

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Transfer of plasmid Hly in vivo in pigs intestine

Cited by 4 publications

References 14 publications

Models for Gut-Mediated Horizontal Gene Transfer by Bacterial Plasmid Conjugation

Models for Gut-Mediated Horizontal Gene Transfer by Bacterial Plasmid Conjugation

Meta-Analysis of Experimental Data Concerning Antimicrobial Resistance Gene Transfer Rates during Conjugation

Antimicrobial Resistance: Implications for the Food System

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