Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance

Schölzel, K.; Schildberg, Frank A.; Welz, Meike; Börner, Carolin; Geiger, Sergej; Kurts, Christian; Heikenwälder, Mathias; Knolle, Percy A.; Wohlleber, Dirk

doi:10.1016/j.jhep.2014.04.028

Cited by 26 publications

(24 citation statements)

References 36 publications

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“…Recent studies challenging the APC function of HSCs show the crucial need for developing new isolation methods to obtain highly pure liver cell populations in the future [26 ]. Although cellular contamination issues may be easier to resolve, artifacts based on in vitro differentiation will require novel model systems and technologies that reflect the complex regulation of intrahepatic immunity.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to LSECs, HSCs are hard to identify based on surface markers, although intracellular GFAP for quiescent and aSMA for activated HSCs have been used. However, a recent publication showed that HSCs can be differentiated from other liver cells using size, granularity, and high UV-fluorescence (due to their vitamin A) in combination with the absence of scavenger activity [26 ]. Once HSCs are activated under inflammatory conditions, they differentiate into myofibroblasts and assume a crucial role in liver fibrogenesis.…”

Section: Hepatic Stellate Cells Weak Antigen-presenting Function Of Hmentioning

confidence: 99%

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Hepatic immune regulation by stromal cells

Schildberg

Sharpe

Turley³

2015

Current Opinion in Immunology

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Section: Discussionmentioning

confidence: 99%

Section: Hepatic Stellate Cells Weak Antigen-presenting Function Of Hmentioning

confidence: 99%

Hepatic immune regulation by stromal cells

Schildberg

Sharpe

Turley³

2015

Current Opinion in Immunology

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“…However, LSECs can cross-present antigens released from Ad-infected hepatocytes and promote TNF-α production by effector CTLs, resulting in the clearance of infected hepatocytes [57]. Interestingly, by using HSC-restricted MHC-I mice, Katrin et al revealed that HSCs transfer MHCI molecules to LSECs and support in vivo LSEC cross-presentation after hepatotropic viral infection [58]. Therefore, although LSECs are the weal APCs, they can promote CTL response through the way of cross-presentation in viral infection.…”

Section: Liver Sinusoidal Endothelial Cellsmentioning

confidence: 99%

Intrahepatic regulation of antiviral T cell responses at initial stages of viral infection

Liang

Kwota

Sun

2016

International Immunopharmacology

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It is generally accepted that the appropriate boost of early immune response will control viral replications and limit the immune-mediated pathology in viral hepatitis. However, poor immunity results in viral persistence, chronic inflammation and finally liver cirrhosis and carcinoma. As a peripheral non-lymphoid organ of immune surveillance, the liver continually encounters hundreds of molecules from the blood, including nutrients, toxins and pathogens. In this way, the liver maintains immune tolerance under healthy conditions, but responds quickly to the hepatotropic pathogens during the early stages of an infection. Although our knowledge of liver cell compositions and functions has been improved significantly in recent years, the intrahepatic immune regulation of antiviral T cells at the initial stage is complex and not well elucidated. Here, we summarize the role of liver cell subpopulations in regulating antiviral T cell response at the initial stages of viral infection. A better understanding of early hepatic immune regulation will pave the way for the development of novel therapies and vaccine design for human viral hepatitis.

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“…One way to investigate the intercellular communication between HSCs and other hepatic cells is co-culturing HSCs with the cell type of interest such as Kupffer cells [53], hepatocytes, LSECs [54], CC [60], and hepatocellular carcinoma cell (HCC) lines [55]. Several experimental approaches can be used depending on what is being investigated.…”

Section: Hsc Co-cultures With Kupffer Cells Hepatocytes Lsec Hcc mentioning

confidence: 99%

Hepatic Stellate Cell Culture Models

Rombouts

2015

Stellate Cells in Health and Disease

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Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance

Cited by 26 publications

References 36 publications

Hepatic immune regulation by stromal cells

Hepatic immune regulation by stromal cells

Intrahepatic regulation of antiviral T cell responses at initial stages of viral infection

Hepatic Stellate Cell Culture Models

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