Transfer of maternal immunity to piglets is involved in early protection against Mycoplasma hyosynoviae infection

Lauritsen, Klara Tølbøll; Hagedorn-Olsen, Tine; Jungersen, Gregers; Riber, Ulla; Stryhn, Henrik; Friis, Ν. F.; Lind, Peter; Kristensen, B.

doi:10.1016/j.vetimm.2016.12.002

Cited by 9 publications

(5 citation statements)

References 39 publications

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“…It is important to take into account that maternally derived antibodies may play a protective role against M . hyosynoviae colonization prior to weaning [13,26], delaying the transmission between piglets post-weaning [14,26], with few colonized piglets acting as carriers. It has been shown that M .…”

Section: Discussionmentioning

confidence: 99%

Mycoplasma hyorhinis and Mycoplasma hyosynoviae dual detection patterns in dams and piglets

2019

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Mycoplasma hyorhinis and M. hyosynoviae are agents associated with arthritis in pigs. This study investigated the tonsillar detection patterns of M. hyorhinis and M. hyosynoviae in a swine population with a history of lameness. The plausibility of dual PCR detection of these agents in dams at one and three weeks post-farrowing and their offspring at the same time was determined. The association between M. hyorhinis and M. hyosynoviae detection in piglets and potential development of lameness in wean-to-finish stages was evaluated by correlating individual piglet lameness scores and PCR detection in tonsils. Approximately 40% of dams were detected positive for M. hyorhinis and M. hyosynoviae at both one and three weeks post-farrowing. In first parity dams, M. hyorhinis was detected in higher proportions (57.1% and 73.7%) at both weeks of sampling compared to multi-parity dams. A lower proportion of first parity dams (37.5%) were detected positive at week one with M. hyosynoviae and an increase in this proportion to 50% was identified in week three. Only 8.3% of piglets were detected positive for M. hyorhinis in week one compared to week three (50%; p<0.05). The detection of M. hyosynoviae was minimal in piglets at both weeks of sampling (0% and 0.9%). Lameness was scored in pigs 5–22 weeks of age, with the highest score observed at week 5. The correlation between PCR detection and lameness scores revealed that the relative risk of developing lameness post-weaning was significantly associated with detection of M. hyorhinis in piglets at three weeks of age (r = 0.44; p<0.05).The detection pattern of M. hyorhinis and M. hyosynoviae in dams did not reflect the detection pattern in piglets. Results of this study suggest that positive detection of M. hyorhinis in piglets pre-weaning could act as a predictor for lameness development at later production stages.

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Section: Discussionmentioning

confidence: 99%

Mycoplasma hyorhinis and Mycoplasma hyosynoviae dual detection patterns in dams and piglets

2019

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“…Pigs are able to mount an immune response to mycoplasmas which has been shown to be protective in vaccination against enzootic pneumonia caused by M hyopneumoniae . Furthermore Lauritsen and others9 have shown that boosting colostral immunity to M hyosynoviae , which normally wanes after one month to two months, by maternal vaccination, extends protection over the early susceptible period of the piglet’s life. Thus the development of an autogenous vaccine may improve the control of mycoplasma arthritis and help reduce dependence on antibiotic usage for controlling infections.…”

Section: Discussionmentioning

confidence: 96%

Diagnosis and control of a severe outbreak of lameness caused byMycoplasma hyosynoviaein a closed pig unit

Moronato

Ustulin

Vio

et al. 2017

Vet Record Case Reports

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Mycoplasma hyosynoviae is a swine pathogen causing arthritic diseases and severe economic losses. The authors report an outbreak of severe lameness in a pig farm in northern Italy in which approximately 35% of the growing herd showed clinical signs. Lameness was not associated with fever, change in appetite or stiffness in the limbs but was mostly related to swelling of the affected joint. M hyosynoviae was cultured from joints and identified by PCR; tests failed to detect the presence of other infectious causes of arthritic diseases. Antibiotic susceptibility tests were carried out on isolates of M hyosynoviae taken from the tissues in order to guide the choice of antibiotics for treatment. In consultation with the farm’s private veterinary surgeon, this was recommended to be a combination of spectinomycin and lincomycin. However the pigs frequently relapsed indicating the need for longer‐term control such as vaccination which should also reduce antibiotic usage.

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“…However, the development of active immunity of newborn piglets is very slow, and their immune system does not protect until 7–8 days after birth. Thus, passive immunity must be obtained by sucking colostrum rich in antibodies to resist the invasion of various pathogenic bacteria ( Kielland et al, 2015 ; Lauritsen et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Early flora colonization affects intestinal immunoglobulin G uptake in piglets, which may be mediated by NF-κB-FcRn pathway

Peng

Zhang²,

He³

et al. 2023

Front. Microbiol.

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IntroductionThe passive immunity of newborn piglets is mainly derived from immunoglobulin G (IgG) in breast milk, and the incomplete transfer of passive immune is considered to be an important cause of piglet death. This study was conducted to investigate the effect of early intestinal flora colonization on IgG uptake and its possible mechanism.MethodsThe newborn piglets and IPEC-J2 cells were used to investigate the possible factors and regulatory mechanisms affecting intestinal IgG uptake. In vivo, all 40 piglets were euthanized on postnatal d 0, 1, 3, and 7, with 10 piglets per time. The blood sample, gastric contents, jejunal contents and mucosa were collected for analysis. In vitro, IPEC-J2 cells transwell culture system was used to establish the IgG transporter model to explore the specific regulatory mechanism of IgG transport.ResultsOur results demonstrated that the intestinal IgG uptake was positively correlated with the expression of Neonatal Fc receptor (FcRn). With the increase of age, the intestinal flora of newborn piglets was gradually enriched. The function of intestinal genes also changes with the colonization of intestinal flora. We found that the expression trend of TLR2, TLR4 and NF-κB (P65) in intestine was consistent with that of FcRn. Furthermore, the in vitro results demonstrate that the NF-κB signaling pathway is involved in regulating FcRn-mediated IgG transmembrane transport.DiscussionEarly flora colonization affects intestinal IgG uptake in piglets, which may be mediated by NF-κB-FcRn pathway.

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Transfer of maternal immunity to piglets is involved in early protection against Mycoplasma hyosynoviae infection

Cited by 9 publications

References 39 publications

Mycoplasma hyorhinis and Mycoplasma hyosynoviae dual detection patterns in dams and piglets

Mycoplasma hyorhinis and Mycoplasma hyosynoviae dual detection patterns in dams and piglets

Diagnosis and control of a severe outbreak of lameness caused byMycoplasma hyosynoviaein a closed pig unit

Early flora colonization affects intestinal immunoglobulin G uptake in piglets, which may be mediated by NF-κB-FcRn pathway

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