Transfer of immunity against long surviving rat skin xenografts by antilymphocyte serum treated Syrian hamsters

Shaffer, Charles F.

doi:10.1097/00007890-197005000-00017

Transplantation

1970

DOI: 10.1097/00007890-197005000-00017

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Transfer of immunity against long surviving rat skin xenografts by antilymphocyte serum treated Syrian hamsters

Charles F. Shaffer¹

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1996

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“…Early studies showed two types of graft rejection responses in xenogeneic combinations (8): discordant hyperacute rejection responses mediated by humoral immunity with natural antibodies and complement (9, lo), and concordant acute rejection responses mediated by cell-mediated cytotoxicity ( I 1). Acute graft rejection responses in concordant xenogeneic combination are mediated by cellular immunity mechanisms similar to these of allograft rejection responses (12). On one hand, recent studies have revealed the usefulness of experimental trials to regulate hyperacute graft rejection responses in discordant xenogeneic combination (13)(14)(15).…”

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confidence: 99%

Evidence of Direct Recognition Subset in Xeno‐reactive Helper T Cells

et al. 1996

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There are two functional subsets of alloreactive helper T cells: one recognizes the alloantigens on self-antigen-presenting cells (APCs), and the other recognizes the alloantigens on allo-APCs. In this study, we analyzed which specific Th cells have a possible effect on concordant-xenograft rejection responses and how Th cells recognize xeno-antigens. In the proliferative response stimulated with spleen cells obtained from rats (r-SPC), mouse T cells (m-Tc) were not inhibited by GK1.5 (CD4) or 2.43 (CD8) antibodies. In a xeno-mixed lymphocyte reaction, m-Tc that included APC (APC(+)) proliferated when stimulated with r-SPC APC(+) or APC(-). In contrast, B6 T cell APC(-) proliferated only when stimulated with r-APC(+)SPC but not when stimulated with APC(-). The m-Tc lines responded to F344 SPC APC(+) but not to SPC APC(-); however, the m-Tc line did not respond to SPC from another rat strain. We hypothesize that both CD4+ Th and CD8+ Th are included in the concordant xeno-reactive Th; there are both xeno-APC-restricted Th and self-APC-restricted Th; and xeno-APC-restricted Th recognizes xeno-major histocompatibility complexes.

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confidence: 99%

Evidence of Direct Recognition Subset in Xeno‐reactive Helper T Cells

et al. 1996

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Transfer of immunity against long surviving rat skin xenografts by antilymphocyte serum treated Syrian hamsters

Cited by 1 publication

References 0 publications

Evidence of Direct Recognition Subset in Xeno‐reactive Helper T Cells

Evidence of Direct Recognition Subset in Xeno‐reactive Helper T Cells

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