Transfer of fatty acids across the rabbit placenta.

Elphick, Martin; Hudson, D.G.; Hull, D

doi:10.1113/jphysiol.1975.sp011132

Cited by 83 publications

(77 citation statements)

References 15 publications

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“…Important differences of FFA transfer to the foetus have been demonstrated between species in relation to their placentation. Maternal FFA are readily transferred in several species like rabbits [11,12,24,56] or guinea pigs [57,58], although in sheep the placenta displays poor permeability to this substrate [13]. This latter observation can be extended to the pig since after meal ingestion the maternal plasma FFA drop and it is not accompanied by a studied previously.…”

Section: Resultsmentioning

confidence: 99%

Effects of meal intake on materno-foetal exchanges of energetic substrates in the pig

Père

2001

Reprod. Nutr. Dev.

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-Catheters were implanted in 18 gilts at 99 days of pregnancy to study the effects of meal intake on uterine and umbilical uptake of energetic substrates in the conscious pig. Blood samples were withdrawn at 105 days of pregnancy from 10 min before and up to 90 min after feeding of a 2.5-kg meal. Plasma glucose was 2.2 to 2.5 times lower and blood lactate 2 to 3 times higher in the foetus than in the sow. Glucose and lactate increased after the meal. Their umbilical uptake amounted to 0.32 and 0.26 mmol . L -1 , respectively. Fructose was found in large amounts in foetal plasma (4.3 mmol . L -1 ), but it did not seem to be metabolised by the foetus. Meal intake decreased plasma levels of FFA and glycerol in the sows, whereas they increased in the foetuses. A small FFA and glycerol umbilical uptake was recorded (14 and 6 µmol . L -1 , respectively). Most features of the maternofoetal exchanges in the porcine species resemble those of other species, especially ruminants. materno-foetal exchange / energetic substrate / meal intake / pig Résumé -Effets de la prise alimentaire sur les échanges materno-foetaux de substrats énergétiques chez le porc. Des cathéters ont été implantés sur 18 truies à 99 jours de gestation afin d'étudier chez l'animal vigile les effets d'une prise alimentaire sur la capture de substrats énergétiques par l'utérus et le foetus. Des échantillons de sang ont été prélevés à 105 jours de gestation entre 10 min avant et 90 min après la distribution d'un repas de 2,5 kg. La glycémie était 2,2 à 2,5 fois plus faible et la lactatémie 2 à 3 fois plus élevée chez le foetus que chez la mère. Elles augmentaient après le repas. La capture de glucose et de lactate par le foetus était respectivement de 0,32 et 0,26 mmol . L -1 . Les concentrations sanguines de fructose étaient élevées chez le foetus (4,3 mmol . L -1 ), mais ce substrat ne semblait pas métabolisé. La consommation du repas provoquait une diminution des teneurs plasmatiques en AGL et en glycérol des truies alors qu'elles augmentaient chez les foetus. Une faible Reprod. Nutr. Dev. 41 (2001) 285-296 285

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Section: Resultsmentioning

confidence: 99%

Effects of meal intake on materno-foetal exchanges of energetic substrates in the pig

Père

2001

Reprod. Nutr. Dev.

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“…Measurements on umbilical blood samples from sheep did not show a net flux in either direction (James, Meschia & Battaglia, 1971). In rabbits and man the umbilical venous-arterial difference varied directly with the maternal FFA blood concentrations (Elphick et al 1975;Elphick et al 1976;Aabata, Wolf & Lausmann, 1968). This would suggest that one factor determining the transfer of fatty acids from the mother to the foetus is the concentration on the maternal side of the placenta.…”

Section: Introductionmentioning

confidence: 90%

“…Infusion of labelled palmitate into foetal rabbits led to its early appearance in the free fatty acid compartment of maternal blood (Elphick, Hudson & Hull, 1975). Thus, fatty acids can be transferred across the placenta in both directions.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, fatty acids can be transferred across the placenta in both directions. Measurements of the difference in concentration of free fatty acids (FFA) in umbilical arterial and venous blood have indicated a net flux of fatty acids to the foetus in rabbits (Elphick et al 1975) and man (Persson & Tunnell, 1971;Sheath, Grimwade, Waldron, Bickley, Taft & Wood 1972;Elphick, Hull & Sanders, 1976). Measurements on umbilical blood samples from sheep did not show a net flux in either direction (James, Meschia & Battaglia, 1971).…”

Section: Introductionmentioning

confidence: 99%

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The transfer of free fatty acids across the rabbit placenta.

Elphick¹,

Hull²

1977

The Journal of Physiology

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SUMMARY1. The passage of fatty acids across the placenta was studied in 28 day pregnant rabbits (i) by comparing the fatty acid distribution in plasma free fatty acids (FFA) of umbilical cord artery and vein with that in maternal plasma and (ii) by infusing the doe at a constant rate with labelled palmitic, linoleic or arachidonic acids. During the infusion maternal and foetal plasma FFA specific activities were measured.2. The mean levels of all the fatty acids studied (from twelve to twenty carbon atoms) were similar in both the umbilical vein plasma and maternal arterial plasma FFA, except for arachidonic acid, which was higher in foetal blood. The relative distribution of the fatty acids in umbilical arterial plasma was similar to that in the vein, but at lower concentrations. The mean cord venous-arterial difference for each fatty acid correlated positively with the mean maternal arterial levels, with the exception of arachidonic acid.3. During the constant infusion experiments the specific activities of the fatty acids in the maternal and foetal circulating FFA pools rose rapidly during the first 4 min then rose only slowly. Palmitic and linoleic acids were cleared from the maternal circulation in a similar manner and crossed the placenta at similar rates.4. The average foetal specific activity in plasma FFA reached 15 % of the maternal level for both palmitate and linoleate. The figure for arachidonic acid was half that for palmitic acid infused at the same time.5. It is concluded that (i) all the major fatty acids present in foetal adipose tissue cross the placenta, (ii) the net transport of each fatty acid depends in part on maternal concentrations, (iii) the rate of metabolism of palmitic and linoleic acids is the same and both cross the placenta at the same rate. Proportionately less foetal arachidonic acid is derived from maternal FFA, and (iv) the results suggest a second placental source of arachidonic acid and possibly also of other fatty acids.

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“…No anabolism has been observed in pregnant rabbits (Lebas, 1975 (Elphick et al, 1975 ;Elphick and Hull, 1977a,b ;Hudson and Hull, 1977 ;Stammers et al, 1983 Robinson and Williamson, 1980). The only data available have shown that blood ketone bodies remain very low throughout pregnancy in rabbits (Gilbert et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Ketone body metabolism during pregnancy in the rabbit

Jean-Blain¹,

Durix²,

Monique³

et al. 1985

Reprod. Nutr. Dévelop.

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Summary. The It is concluded that ketonemia was enhanced in late gestation, particularly with restricted feeding or in fasted animals ; this enhancement was partly related to the increase of plasma NEFA concentrations and partly to the enhancement of hepatic ketogenesis in the mothers. The fact that the rate of hepatic ketogenesis was increased equally with butyrate and oleate indicated that it could not be explained by a modification of acylcarnitine transferase activity as butyrate directly crosses the mitochondrial membrane without using this pathway.Introduction.

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Transfer of fatty acids across the rabbit placenta.

Cited by 83 publications

References 15 publications

Effects of meal intake on materno-foetal exchanges of energetic substrates in the pig

Effects of meal intake on materno-foetal exchanges of energetic substrates in the pig

The transfer of free fatty acids across the rabbit placenta.

Ketone body metabolism during pregnancy in the rabbit

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