Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta

Ala‐Kokko, Tero; Pienimäki, P.; Lampela, E.; Hollmén, A; Pelkonen, Olavi; Vähäkangas, Kirsi

doi:10.1111/j.1399-6576.1997.tb04685.x

Cited by 80 publications

(44 citation statements)

References 23 publications

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“…The results showed no difference in the Apgar score, heart rate or NACS compared with the control group. The α 2 -agonist clonidine was safely used as an intrathecal supplement in cesarean sections 34,35) ; however, dexmedetomidine eliminates faster than clonidine in maternal circulation and much less in fetal circulation, 36) thus, theoretically, dexmedetomidine is safer for babies than clonidine.…”

Section: )mentioning

confidence: 99%

Comparison of Intrathecal Dexmedetomidine with Morphine as Adjuvants in Cesarean Sections

Chen

et al. 2016

Biological & Pharmaceutical Bulletin

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To compare the effects of intrathecal dexmedetomidine and intrathecal morphine as supplements to bupivacaine in cesarean sections under spinal anesthesia. Full-term parturients (n 120) undergoing elective cesarean sections under spinal anesthesia were randomly allocated into three groups: Group B received 10 mg bupivacaine, Group BD received 10 mg bupivacaine plus 5 µg dexmedetomidine, and Group BM received 10 mg bupivacaine plus 100 µg morphine. The onset and regression time of sensory and motor blockade, postoperative analgesia, and side effects were recorded. Group BD showed quicker onset time and a longer sensory and motor blockade than other groups (BD vs. B and BD vs. BM, p<0.05). The mean time of sensory regression to the S1 segment was 253.21 42.79 min in group BD, 192.50 40.62 min in group BM and 188.33 37.62 min in group B (p<0.001). Group BD showed an analgesia duration (time to requirement of first rescue analgesic) (17.59 6.23 h) similar to that of group BM (16.78 5.90 h) but longer than that of group B (3.53 1.68 h) (p<0.001). The incidence of pruritus was significantly higher in group BM compared with groups BD and B (p<0.001). Less shivering was observed in group BD than in groups BM and B ( p 0.009). So intrathecal dexmedetomidine (5 µg) prolonged the motor and sensory blockade, provided a similar analgesic effect and reduced pruritus and shivering compared with morphine (100 µg) in cesarean sections.

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Section: )mentioning

confidence: 99%

Comparison of Intrathecal Dexmedetomidine with Morphine as Adjuvants in Cesarean Sections

Chen

et al. 2016

Biological & Pharmaceutical Bulletin

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“…Dexometomedine has high lipophilicity and so it passes through placenta but it disappears very fast [44]. Mahdy et al, found that after intrathecal dexmedetomidine injection there were significantly longer sensory and motor block times than patients in control and fentanyl group and there were no adverse effects on mothers or babies in any group [45].…”

Section: Obstetric Usementioning

confidence: 99%

Dexmedetomidine in Current Anaesthesia Practice- A Review

NAAz

Ozair

2014

JCDR

121

124

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“…Os autores justificaram o aumento no tempo de sedação, embora tenha havido diminuição na meia vida de eliminação, pela menor ligação protéica do medicamento nestes pacientes. Ala-Kokko e col. 23 compararam a transferência placentária da dexmedetomidina e da clonidina em modelo experimental de cotilédones placentários humanos perfundidos. Houve maior retenção placentária da dexmedetomidina, diminuindo a exposição da droga do lado fetal.…”

Section: Farmacocinética E Farmacodinâmicaunclassified

Uso de dexmedetomidina em anestesiologia

Villela¹,

Júnior²

2003

Rev. Bras. Anestesiol.

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RESUMO e d i c a ç ã o p r é -a n e s t é s i c a , o u d u r a n t e o a t o anestésico-cirúrgico. O mecanismo de ação dos fármacos a 2 -a g o n i s ta s e a s p r o p r i e d a d e s f a r m a c o c i n é t i c a s e farmacodinâmicas da dexmedetomidina também são revistos neste artigo. Conclusões -O uso da dexmedetomidina como medicação p r é -a n e s t é s i c a , d u r a n t e a n e s t e s i a , o u n o p e r í o d o pós-operatório

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Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta

Abstract: Dexmedetomidine disappeared faster than clonidine from the maternal circulation, while even less dexmedetomidine was transported into the fetal circulation. This was due to its greater placental tissue retention, the basis for which probably is the higher lipophilicity of dexmedetomidine.

Cited by 80 publications

References 23 publications

Comparison of Intrathecal Dexmedetomidine with Morphine as Adjuvants in Cesarean Sections

Comparison of Intrathecal Dexmedetomidine with Morphine as Adjuvants in Cesarean Sections

Dexmedetomidine in Current Anaesthesia Practice- A Review

Uso de dexmedetomidina em anestesiologia

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