Transfer of Clarithromycin to Gastric Juice is Enhanced by Omeprazole in Helicobacter pylori -Infected Individuals

Pedrazzoli, José; Calafatti, Silvana A.; Ortiz, Rodrigo A.; Dias, Fernanda E.; Deguer, Maristela; Mendes, Fabiana D.; Bento, Ana Paula Nunes; Pereira, A; Piovesana, H.; Ferraz, José G.; Lerner, F. E.; Nucci, Gilberto De

doi:10.1080/003655201317097074

Cited by 18 publications

(1 citation statement)

References 23 publications

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“…Co-administration of CLR with proton pump inhibitors (PPIs), such as esomeprazole [171], lansoprazole [151,172–175], omeprazole [176–179], pantoprazole [176], and rabeprazole [180]—a combination commonly prescribed as part of Helicobacter pylori treatment—has been investigated in several studies. A double-blinded RCT in 18 healthy volunteers of different genotype groups of CYP2C19 found an increase of approximately 110% of the AUC and C max of (S) -lansoprazole in extensive metabolizers (EMs) [172].…”

Section: Resultsmentioning

confidence: 99%

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

et al. 2011

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Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams, focusing on systematic research. We describe drug-food and drug-drug interaction studies in humans, affecting antimicrobial drugs as well as concomitantly administered drugs. Since knowledge about mechanisms is of paramount importance for adequate management of drug interactions, the most plausible underlying mechanism of the drug interaction is provided when available. This overview can be used in daily practice to support the management of pharmacokinetic drug interactions of antimicrobial drugs.

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Section: Resultsmentioning

confidence: 99%

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

et al. 2011

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Helicobacter pylori treatment in children: Defining a dose for rabeprazole as a part of a triple therapy regimen

Kimko

Thyssen

Mould

et al. 2015

The Journal of Clinical Pharma

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The proton pump inhibitor, rabeprazole, has been studied in children for the treatment of gastroesophageal reflux disease (GERD). In adults, rabeprazole is indicated for Helicobacter pylori eradication in combination with amoxicillin and clarithromycin. Nonlinear mixed effects modeling was conducted to estimate pharmacokinetic (PK) parameters for rabeprazole and its thioether metabolite from 336 subjects, 35% of whom were children 1-11 years with GERD from phase I and III studies. A 2-compartment disposition model with a transit absorption model provided the best fit for rabeprazole PK. The steady-state area under the concentration-time curves given several candidate doses were simulated to identify a dose per each body weight group that is comparable to a 20 mg twice-daily dose in adults, which is the recommended dose for treatment of H. pylori in adults. Simulations provided the following recommended twice-daily weight-based doses for children ≥1 year and <16 years: 10 mg for 6-10 kg, 15 mg for 10-30 kg, and 20 mg for ≥30 kg.

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Pharmacotherapy of Helicobacter pylori-associated gastritis

Romano

Cuomo

2004

Pharmacotherapy of Gastrointestinal Inflammation

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Transfer of Clarithromycin to Gastric Juice is Enhanced by Omeprazole in Helicobacter pylori -Infected Individuals

Cited by 18 publications

References 23 publications

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

Helicobacter pylori treatment in children: Defining a dose for rabeprazole as a part of a triple therapy regimen

Pharmacotherapy of Helicobacter pylori-associated gastritis

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