In this article, the natural frequencies of curved pipe conveying non-uniform axial flow are calculated. The non-uniformity of velocity distribution on the section is considered and the parabola fluid is adopted in the section. The Flügge curved beam is used to build the pipe model. The dynamic equation of pipe conveying non-uniform fluid is derived based on Hamilton principle. The wave propagation method is used to solve the equation. With different flow velocity, the natural frequency is computed in the assumption of non-uniform fluid and uniform fluid. Compared with the uniform fluid, the non-uniform fluid will have a higher frequency value.