Transfer Factor for the Lung and ‘Emphysema Score’

Téculescu, D; Racoveanu, C; Manicatide, M

doi:10.1159/000193047

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…This is in agreement with more impaired lung function than the pa-the results of other authors [21][22][23][24][25][26]. The tients without emphysema (table I-111).…”

Section: Discussionsupporting

confidence: 88%

Pulmonary Emphysema and the Crossover Point

Kreukniet

Vries²,

Brink

1984

Respiration

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In 13 healthy subjects and 34 patients with chronic obstructive lung disease (COLD) (23 patients without and 11 patients with emphysema) the breath number at crossover point, using He and SF₆ as test gases, and some pulmonary functions (spirometry, body plethysmography and washout curves) were investigated. Although the patients with emphysema did show a more severely impaired lung function than the patients without emphysema, no clear lung function pattern for patients with emphysema was demonstrated in comparison to the patients without emphysema. The pattern of the breath number at crossover point was unpredictable. Most probably this breath number is more related to the severity of impaired gas mixing than to the degree of emphysema. So the clinical diagnosis of emphysema in patients with COLD remains difficult, in spite of the use of advanced technology for fast and accurate analysis by mass spectrometry

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“…This is in agreement with more impaired lung function than the pa-the results of other authors [21][22][23][24][25][26]. The tients without emphysema (table I-111).…”

Section: Discussionsupporting

confidence: 88%

Pulmonary Emphysema and the Crossover Point

Kreukniet

Vries²,

Brink

1984

Respiration

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“…In emphyse ma, reduction of Dco parallels the severity of the emphysematous disease of the lung. These observations are confirmed by many authors [Forster, 1965;Bates et al, 1971;Teculescu et al, 1973;Cotes, 1975].…”

Section: Dco Values In the Literaturesupporting

confidence: 74%

D<sub>CO</sub> at Various Breath-Holding Times: Comparison in Patients with Chronic Bronchial Asthma and Emphysema

Magnussen¹,

J²,

Hartmann³

et al. 1979

Respiration

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Measurement of D_CO is known to be dependent upon functional inhomogeneities. Because different types of inhomogeneities are operative in patients with bronchial asthma and patients with emphysema, different changes of D_CO with increasing breath-holding time, t_A, are to be expected. We studied the change of Dco with increasing breath-holding time in healthy subjects, patients with asthma bronchiale and patients with emphysema. In the patients the severity of airway obstruction was about the same. The following results were obtained: (a) in healthy subjects and in the asthmatics D_CO decreased with t_A, in a similar manner, approaching a value (ml·min^-1·Terror^-1) of 34.7 and 31.6 at 10 sec, respectively, and (b) in patients with emphysema D_CO increased with t_A, yielding negative values at small t_A: 1.5 sec-23.4; 10 sec: 11.7.From these results we suggest that in healthy subjects and in patients with bronchial asthma parallel inhomogeneities influence the course of D_CO. In emphysema the time course of D_CO is best explained with a faster intrapulmonary mixing of He compared to CO. This behavior indicates that in emphysema low D_CO values can be mainly attributed to large diffusional resistances (stratification) within the lungs.

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Retrospectroscope: The single breath test of diffusing capacity for carbon monoxide

Rosenberg

1977

Medical Hypotheses

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Transfer Factor for the Lung and ‘Emphysema Score’

Cited by 4 publications

References 15 publications

Pulmonary Emphysema and the Crossover Point

Pulmonary Emphysema and the Crossover Point

D<sub>CO</sub> at Various Breath-Holding Times: Comparison in Patients with Chronic Bronchial Asthma and Emphysema

Retrospectroscope: The single breath test of diffusing capacity for carbon monoxide

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